Viruses and Apoptosis

  • Covadonga Alonso

Part of the Progress in Molecular and Subcellular Biology book series (PMSB, volume 36)

Table of contents

  1. Front Matter
    Pages I-XVI
  2. M. Barry, S. T. Wasilenko, T. L. Stewart, J. M. Taylor
    Pages 19-37
  3. A. Müllbacher, R. V. Blanden
    Pages 39-55
  4. Pablo M. Irusta, J. Marie Hardwick
    Pages 71-93
  5. B. Blondel, T. Couderc, Y. Simonin, A.-S. Gosselin, F. Guivel-Benhassine
    Pages 151-169
  6. A. Cetteau, M.-P. Courageot, P. Desprès
    Pages 171-189
  7. P. Feng, C. Scott, S.-H. Lee, N.-H. Cho, J. U. Jung
    Pages 191-205
  8. I. Alasdair Russell, J. A. Royds, A. W. Braithwaite
    Pages 207-243
  9. M. Carbone, M. Bocchetta
    Pages 289-305
  10. P. F. Valerón, S. Aznar-Benitah, J. C. Lacal
    Pages 307-323
  11. Back Matter
    Pages 325-342

About this book


The pathogenesis of viral infections involves dynamic interactions between viruses and hosts,which can result in different outcomes including cell death, elimination of the virus or latent infection.Viruses deliver genomes and p- teins with signaling potential into target cells, resulting in growth, prolife- tion and apoptosis.Viral infection modi?es key cell regulatory elements involved in apoptotic pathways to successfully accomplish viral replication despite the toxicity of viral products and the immune response elicited against the virus.Also,the interplay between virus-induced apoptosis and cell survival is mediated by an accurate balance between pro-death and anti-apoptotic signals triggered by cellular and viral proteins.Hence,viral survival products causing a delay in the completion of apoptotic process can be critical in the replication and propagation of viruses. Viral control of apoptosis can be a double-edged sword.In some viral inf- tions, immune cell apoptosis will contribute to pathogenesis and determine disease evolution either by direct infection of immune cells or as a result of bystander cell apoptosis caused by viral proteins or mediators secreted from infected cells. The apoptotic mechanisms contributing to HIV pathogenesis, the functional consequences on the immune system and the effect of antiviral therapies on this process will be reviewed in depth in this Volume.


HIV Herpes Virus Viruses apoptosis cell cell cycle cell death immunity oncogene oncogenes pathogenesis protein regulation virology virus

Editors and affiliations

  • Covadonga Alonso
    • 1
  1. 1.Dpt. BiotechnologiaINIAMadridSpain

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2004
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-74263-0
  • Online ISBN 978-3-540-74264-7
  • Series Print ISSN 0079-6484
  • Buy this book on publisher's site