Specialization and Complementation of Humoral Immune Responses to Infection

  • Tim┬áManser
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 319)

Table of contents

  1. Front Matter
    Pages i-xii
  2. N. Baumgarth, Y. S. Choi, K. Rothaeusler, Y. Yang, L. A. Herzenberg
    Pages 41-61
  3. Back Matter
    Pages 157-162

About this book

Introduction

In recent years the results of past studies on T cell dependent and T cell independent antibody responses have coalesced with discoveries regarding the roles of various primary B cell subsets and components of the innate immune system in conferring resistance to infectious pathogens. As a consequence, a new and more complete understanding of how antibody-mediated resistance to pathogens is elaborated has emerged. The recent explosion of knowledge of Toll-like receptor specificity and function has further embellished this understanding. It is now clear that there is not only extensive overlap and cross-complementarity in the action of innate and adaptive immune systems, but also specialization of function of the various B cell subsets and the types of antibodies they produce. This synergistic interaction of multiple components of these systems is perhaps best exemplified in antibody responses to bacteria. Contributions to this monograph were chosen to highlight this new perspective on antibody responses to infection, as well as to convey its practical implications, such as for contemporary vaccine design.

Keywords

Antigen B cells T cells bacteria borrelia infection complement immunization infection infections infectious natural killer streptococcus infection toll-like receptor tumor necrosis factor vaccine

Editors and affiliations

  • Tim┬áManser
    • 1
  1. 1.Department of Microbiology and ImmunologyJefferson Medical CollegePhiladelphiaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-540-73900-5
  • Copyright Information Springer-Verlag Berlin Heidelberg 2008
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-73899-2
  • Online ISBN 978-3-540-73900-5
  • Series Print ISSN 0070-217X