Book 2008

Telomeres and Telomerase in Ageing, Disease, and Cancer

Molecular Mechanisms of Adult Stem Cell Ageing

Editors:

ISBN: 978-3-540-73708-7 (Print) 978-3-540-73709-4 (Online)

Table of contents (14 chapters)

  1. Front Matter

    Pages i-xiv

  2. Telomere Shortening and Ageing

    1. No Access

      Chapter

      Pages 3-22

      Cellular versus Organismal Aging

    2. No Access

      Chapter

      Pages 23-42

      Telomere-Induced Senescence of Primary Cells

    3. No Access

      Chapter

      Pages 43-56

      Telomeres, Senescence, Oxidative Stress, and Heterogeneity

    4. No Access

      Chapter

      Pages 57-75

      Initiation of Genomic Instability, Cellular Senescence, and Organismal Aging by Dysfunctional Telomeres

    5. No Access

      Chapter

      Pages 77-107

      Telomerase Mutations and Premature Ageing in Humans

  3. Telomerase, Telomeres, and Stem Cell Aging

    1. No Access

      Chapter

      Pages 111-140

      Mechanisms of Stem Cell Ageing

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      Chapter

      Pages 141-159

      Senescence Signatures of Human Hematopoietic Stem Cells

    3. No Access

      Chapter

      Pages 161-180

      Telomere Shortening Induces Cell Intrinsic Checkpoints and Environmental Alterations Limiting Adult Stem Cell Function

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      Chapter

      Pages 181-202

      p16INK4a and Stem Cell Ageing: A Telomere-Independent Process?

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      Chapter

      Pages 203-210

      Telomerase as a Potential Regulator of Tissue Progenitor Cells

  4. Telomeres, DNA Damage and Cancer

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      Chapter

      Pages 213-228

      Telomere Shortening and Telomerase Activation during Cancer Formation

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      Chapter

      Pages 229-244

      Telomere Binding Proteins and Disease

  5. Therapeutic Targets

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      Chapter

      Pages 247-283

      Targeting Telomerase: Therapeutic Options for Cancer Treatment

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      Chapter

      Pages 285-308

      Werner Syndrome, Telomeres, and Stress Signaling: Implications for Future Therapies?

  6. Back Matter

    Pages 309-328