Telomeres and Telomerase in Ageing, Disease, and Cancer

Molecular Mechanisms of Adult Stem Cell Ageing

  • K. Lenhard Rudolph

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Telomere Shortening and Ageing

    1. Andrew Dillin, Jan Karlseder
      Pages 3-22
    2. Richard Allsopp
      Pages 23-42
    3. João F. Passos, Glyn Nelson, Thomas von Zglinicki
      Pages 43-56
    4. Hong-Yan Du, Monica Bessler, Philip J. Mason
      Pages 77-107
  3. Telomerase, Telomeres, and Stem Cell Aging

    1. Amanda Waterstrat, Erin Oakley, Alison Miller, Carol Swiderski, Ying Liang, Gary Van Zant
      Pages 111-140
    2. Stefan Zimmermann, Uwe M. Martens
      Pages 141-159
  4. Telomeres, DNA Damage and Cancer

  5. Therapeutic Targets

  6. Back Matter
    Pages 309-328

About this book

Introduction

The understanding of the molecular mechanisms underlying the ageing process is essential to improve quality of life and ‘health span’ in the growing populations of the elderly.

Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes experimental evidence and clinical data indicating that telomere dysfunction influences human ageing, diseases and cancer. In addition, the book describes our current knowledge on checkpoints that limit cellular lifespan (senescence) and survival (apoptosis, crisis) in response to telomere dysfunction.

A special focus of the book is on adult stem cells. There is emerging evidence that adult stem cell ageing impairs organismal fitness and survival and contributes to cancer formation (cancer stem cells). The book summarizes basic mechanisms of adult stem cell ageing. Moreover, the authors describe evidence that telomere dysfunction impairs stem cell function by inducing cell intrinsic checkpoints as well as environmental alterations.

All of these subjects are of great interest for ageing researchers, physicians and students and should provide a rational basis for beginning to identify molecular targets for novel therapies that aim to improve quality of life during ageing.

Keywords

Ageing DNA Telomere aging apoptosis cancer cell cell lines development influence molecular mechanisms proliferation senescence stem cell stem cells

Editors and affiliations

  • K. Lenhard Rudolph
    • 1
  1. 1.University of UlmGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-540-73709-4
  • Copyright Information Springer-Verlag Berlin Heidelberg 2008
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-73708-7
  • Online ISBN 978-3-540-73709-4
  • About this book