Protein-Protein Interactions as New Drug Targets

  • Enno Klussmann
  • John Scott

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 186)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Organization of Scaffolds

    1. K. L. Dodge-Kafka, A. Bauman, M. S. Kapiloff
      Pages 3-14
    2. V. V. Gurevich, E. V. Gurevich, W. M. Cleghorn
      Pages 15-37
  3. Scaffolding Proteins and Cellular Signalling

  4. Cell Type-Specific Anchoring

    1. N. L. Chudasama, S. O. Marx, S. F. Steinberg
      Pages 301-325
    2. K. M. Torgersen, E. M. Aandahl, K. Taskén
      Pages 327-363
  5. Interference with Protein-Protein Interaction Sites as a New Pharmacological Concept

About this book

Introduction

Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effects than conventional medication influencing whole cell functions.

This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.

Keywords

Compartimentalisation Peptide Disruptors Protein-Protein Interactions Scaffolding Proteins Small Molecules proteins

Editors and affiliations

  • Enno Klussmann
    • 1
  • John Scott
    • 2
  1. 1.Leibniz-Institut für Molekulare PharmakologieBerlinGermany
  2. 2.The Vollum InstituteOregon Health & Science UniversityPortlandUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-540-72843-6
  • Copyright Information Springer Berlin Heidelberg 2008
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-72842-9
  • Online ISBN 978-3-540-72843-6
  • Series Print ISSN 0171-2004
  • About this book