ALERT - Adverse Late Effects of Cancer Treatment

Volume 1: General Concepts and Specific Precepts

  • Philip Rubin
  • Louis S. Constine
  • Lawrence B. Marks

Part of the Medical Radiology book series (MEDRAD)

Also part of the Radiation Oncology book sub series (Med Radiol Radiat Oncol)

Table of contents

  1. Front Matter
    Pages i-xxiv
  2. Craig C. Earle, Lois B. Travis, Louis S. Constine
    Pages 1-7
  3. Philip Rubin, George Casarett
    Pages 9-26
  4. Isabel L. Jackson, Phil Rubin, Caroline Hadley, Zeljko Vujaskovic
    Pages 41-51
  5. Paul R. Graves, Isabel Jackson, Mitchell S. Anscher, Ross Mikkelsen, Zeljko Vujaskovic
    Pages 53-64
  6. Chunkit Fung, Kishan J. Pandya
    Pages 123-152
  7. Andrea K. Ng, Melissa M. Hudson
    Pages 153-169
  8. Arnold C. Paulino, Sughosh Dhakal, Louis S. Constine
    Pages 171-180
  9. Barry S. Rosenstein
    Pages 181-189
  10. Joel S. Greenberger, Michael W. Epperly
    Pages 191-203
  11. David J. Brenner, Igor Shuryak, Rainer K. Sachs
    Pages 205-226
  12. Lois B. Travis, Andrea K. Ng
    Pages 227-239
  13. David C. Hodgson, Andrea Ng, Lois B. Travis
    Pages 241-255
  14. Jason Q. Purnell, Karen Mustian, Pascal Jean-Pierre, Oxana Palesh, Luke J. Peppone, Supriya G. Mohile et al.
    Pages 257-272
  15. Sheila Judge Santacroce, Madelyn Rubin
    Pages 273-284
  16. Andre Konski
    Pages 285-291
  17. C. Norman Coleman, Nathaniel Hafer, Bert Maidment, Ronald Manning, Pat Prasanna, Paul Okunieff
    Pages 293-311

About this book


The literature on the late effects of cancer treatment is widely scattered in different journals since all major organ systems are affected and management is based on a variety of medical and surgical treatments. The aim of ALERT – Adverse Late Effects of Cancer Treatment is to offer a coherent multidisciplinary approach to the care of cancer survivors. The central paradigm is that cytotoxic multimodal therapy results in a perpetual cascade of events that affects each major organ system differently and is expressed continually over time. Essentially, radiation and chemotherapy are intense biologic modifiers that allow for cancer cure and cancer survivorship but accelerate senescence of normal tissues and increase the incidence of age-related diseases and second malignant tumors. Volume 1 of this two-volume work focuses on the general concepts and principles relevant to late effects and on the dynamic interplay of molecular, cytologic and histopathologic events that lead to altered physiologic and metabolic functions and their clinical manifestations. Chapters are also included on legal issues, economic aspects, nursing, psychological issues and quality of life.


Cancer Treatment Chemotherapy Late Affects Radiation Radiotherapy

Editors and affiliations

  • Philip Rubin
    • 1
  • Louis S. Constine
    • 2
  • Lawrence B. Marks
    • 3
  1. 1.Dept. Radiation OncologyUniversity of Rochester Medical Center James P. Wilmot Cancer Ctr.RochesterUSA
  2. 2.Department of Radiation OncologyUniversity of Rochester Medical Center James P. Wilmot Cancer Ctr.RochesterUSA
  3. 3.Department of Radiation OncologyUniversity of North CarolinaChapel HillUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2014
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine
  • Print ISBN 978-3-540-72313-4
  • Online ISBN 978-3-540-72314-1
  • Series Print ISSN 0942-5373
  • Series Online ISSN 2197-4187
  • Buy this book on publisher's site