Human Antibody Therapeutics for Viral Disease

  • Scott K. Dessain

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 317)

Table of contents

  1. Front Matter
    Pages i-xi
  2. K. Machida, Z. Y. Keck, M. M. C. Lai, J. K. Ball, A. H. Patel, S. K. H. Foung
    Pages 1-38
  3. M. Huber, W. C. Olson, A. Trkola
    Pages 39-66
  4. T. Nagarajan, Charles E. Rupprecht, Scott K. Dessain, P. N. Rangarajan, D. Thiagarajan, V. A. Srinivasan
    Pages 67-101
  5. H. Wu, D. S. Pfarr, G. A. Losonsky, P. A. Kiener
    Pages 103-123
  6. Scott K. Dessain, S. P. Adekar, J. D. Berry
    Pages 155-183
  7. Back Matter
    Pages 185-190

About this book


The articles in this volume have been selected to demonstrate the progress in the development of human antibody therapeutics for viral disease. Keck et al. review the nature of the immune response to the Hepatitis C virus (HCV) and the details of viral neutralization by antibodies, providing a conceptual model for the clinical use of HCV-specific antibodies. Huber et al. summarize the initial clinical experiences with antibody therapeutics for Human Immunodeficiency Virus that can be targeted to either the HIV virion or to host cell proteins. A discussion of the breadth immune strategies that is required to control human rabies is provided by Nagarajan et al., with a particular focus on India and other countries in which rabies is endemic. The development of pavilizumab for RSV prophylaxis is reviewed in Wu et al., in addition to results of antibody optimization studies that provide surprising insights and have broad general implications for anti-viral antibody engineering. Melhop and Diamond explicate the biology of West Nile Virus as a general model for flaviviruses, while using their cloned antibodies as a springboard to consider the mechanisms of WNV neutralization. The volume concludes with a description of methods to clone human antibodies in their native configurations, which access a class of antibodies that differ from those obtained by recombinant DNA or transgenic mouse methods.

The articles in this volume are definitive and comprehensive reviews written by experts who have sought to define the principles of viral neutralization by human antibodies. They explore and anticipate the obstacles and opportunities that will be encountered as the power of human antibodies is harnessed to address the vast, un-met need for effective anti-viral therapeutics.


Antigen HIV Hepatitis Hepatitis C Virus RSV West Nile Virus antibody diseases immunoglobulin infection infectious infectious disease infectious diseases vaccine virus

Editors and affiliations

  • Scott K. Dessain
    • 1
  1. 1.Thomas Jefferson UniversityPhiladelphiaUSA

Bibliographic information