Protein Engineering

  • Caroline Köhrer
  • Uttam L. RajBhandary

Part of the Nucleic Acids and Molecular Biology book series (NUCLEIC, volume 22)

Table of contents

  1. Front Matter
    Pages i-xi
  2. N. M. Goodey, S. J. Benkovic
    Pages 1-27
  3. S. I. van Kasteren, P. Garnier, B. G. Davis
    Pages 97-125
  4. K. E. Beatty, D. A. Tirrell
    Pages 127-153
  5. A. P. Mascarenhas, S. An, A. E. Rosen, S. A. Martinis, K. Musier-Forsyth
    Pages 155-203
  6. Back Matter
    Pages 339-347

About this book


Site-specific mutagenesis of DNA, developed some thirty years ago, has proven to be one of the most important advances in biology. By allowing the site-specific replacement of any amino acid in a protein with one of the other nineteen amino acids, it ushered in the new era of "Protein Engineering". The field of protein engineering has, however, evolved rapidly since then and the last fifteen years have witnessed remarkable advances through the use of new chemical, biochemical and molecular biological tools towards the synthesis and manipulation of proteins. The chapters included in this book reflect the rapid evolution of protein engineering and its many applications in basic research, biotechnology, material sciences and therapy. This book will provide the reader with an introduction to state-of the-art concepts and methods and will be of use to anyone interested in the study of proteins, in academia as well as in industry.


Amino acid DNA Genetic code expansion Peptide Protein modification Unnatural amino acids Vivo biotechnology chimera enzymes membrane proteins mutagenesis protein proteins translation

Editors and affiliations

  • Caroline Köhrer
    • 1
  • Uttam L. RajBhandary
    • 1
  1. 1.Department of BiologyMassachusetts Institute of TechnologyCambridgeUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Berlin Heidelberg 2009
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-70937-4
  • Online ISBN 978-3-540-70941-1
  • Series Print ISSN 0933-1891
  • Buy this book on publisher's site