Plant-produced Microbial Vaccines

  • Alexander V. Karasev

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 332)

Table of contents

  1. Front Matter
    Pages i-x
  2. M. L. Smith, W. P. Fitzmaurice, T. H. Turpen, K. E. Palmer
    Pages 13-31
  3. K. Ko, R. Brodzik, Z. Steplewski
    Pages 55-78
  4. R. W. Hammond, L. G. Nemchinov
    Pages 79-102
  5. Back Matter
    Pages 119-120

About this book

Introduction

In recent years, plants have been increasingly explored for production of biomedicines and vaccine components. The two main advantages of plant systems are low cost and a greater potential for scalability as compared to microbial or animal systems. An additional advantage from the public health point of view is high safety compared to animal systems, which is important for vaccine production: there are no known plant pathogens capable of replicating in animals, and in humans in particular. A particular antigen or a protein has to be expressed in a plant using one of many available platforms; this antigen/protein subsequently needs to be purified or processed, and later formulated into a vaccine or a therapeutic; these need to be delivered to a human or animal body via an appropriate route. Naturally, all these vaccines and therapeutics must be subjected to regulatory approvals prior to their use. Thus, the challenge is to adapt plant-based platforms for production of cost-efficient biomedicals that can be approved by FDA for use as vaccine components or therapeutics which will be competitive against existing vaccines and drugs. Production of vaccine components and other biomedicals in plants has a great potential in medicine and veterinary science.

Keywords

Antigen antibody biomedicine chloroplasts hepatitis hepatitis B norovirus plant vaccines porcine transmissible gastroenteritis virus protein research tobacco mosaic virus transgenic plant-derived antigens vaccine virus

Editors and affiliations

  • Alexander V. Karasev
    • 1
  1. 1.Department of Plant, Soil & Entomological SciencesUniversity of IdahoMoscowUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-540-70868-1
  • Copyright Information Springer Berlin Heidelberg 2009
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-70857-5
  • Online ISBN 978-3-540-70868-1
  • Series Print ISSN 0070-217X
  • About this book