T Cell Activation by CD1 and Lipid Antigens

  • D. Branch Moody
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 314)

Table of contents

  1. Front Matter
    Pages I-VII
  2. Molecular Biology

    1. Front Matter
      Pages 1-1
    2. C. C. Dascher
      Pages 3-26
    3. D. M. Zajonc, I. A. Wilson
      Pages 27-50
    4. G. De Libero, L. Mori
      Pages 51-72
    5. B. E. Willcox, C. R. Willcox, L. G. Dover, G. Besra
      Pages 73-110
  3. Cellular Biology

    1. Front Matter
      Pages 111-111
    2. S. K. Dougan, A. Kaser, R. S. Blumberg
      Pages 113-141
    3. B. A. Sullivan, M. Kronenberg
      Pages 165-193
    4. H. R. MacDonald, M. P. Mycko
      Pages 195-212
  4. Disease

    1. Front Matter
      Pages 213-213
    2. S. M. Behar, S. A. Porcelli
      Pages 215-250
    3. E. H. Meyer, R. H. DeKruyff, D. T. Umetsu
      Pages 269-291
    4. J. B. Swann, J. M. C. Coquet, M. J. Smyth, D. I. Godfrey
      Pages 293-323
    5. V. Cerundolo, M. Salio
      Pages 325-340
  5. Back Matter
    Pages 341-348

About this book

Introduction

For decades, T cells were thought to solely respond to protein-derived antigens. However, the discovery of the CD1 antigen presenting system shows how antigen presenting cells can display lipid antigens to T cells. Crystal structures show that CD1 proteins accomplish this function by inserting lipids into a hydrophobic groove on the distal surface of the protein, forming CD1-lipid complexes that act as ligands for T cell receptors. CD1-reactive T cells with conserved (NK T cells) or diverse T cell receptors possess cytokine secretion and other effector mechanisms that influence many aspects of immune response. There is increasing evidence that the CD1 system has been conserved throughout mammalian evolution and is capable of presenting structurally diverse diacyglycerol, sphingolipid, polyisoprenol and lipopeptide antigens. These features of CD1 antigen presentation systems now point to a new and expanded view of the natural function of ab T cells, which involves surveillance of both the protein and lipid components of target cells. Further, cellular systems that were previously considered to have functions in lipid metabolism can now be studied in context of their immunological functions. This volume provides a comprehensive discussion of these basic aspects of CD1 biology and summarizes the most recent research into the role of CD1 in infectious, autoimmune, allergic and neoplastic disease.

Keywords

Antigen NKT cells T cell antigen presentation autoimmune disease autoimmunity bacteria bacterial lipid antigens diseases infectious disease molecular biology protein proteins self lipid antigens tumor immunity

Editors and affiliations

  • D. Branch Moody
    • 1
  1. 1.Brigham and Women’s HospitalHarvard Medical SchoolBostonUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-540-69511-0
  • Copyright Information Springer-Verlag Berlin Heidelberg 2007
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-69510-3
  • Online ISBN 978-3-540-69511-0
  • Series Print ISSN 0070-217X