Signalling from Internalized Growth Factor Receptors

  • Inger Helene Madshus

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 286)

Table of contents

  1. Front Matter
    Pages i-ix
  2. M. A. Barbieri, T. P. Ramkumar, S. Fernadez-Pol, P. I. Chen, P. D. Stahl
    Pages 1-20
  3. D. E. Hammond, S. Carter, M. J. Clague
    Pages 21-44
  4. G. J. Strous, C. Alves dos Santos, J. Gent, R. Govers, M. Sachse, J. Schantl et al.
    Pages 81-118
  5. F. Gesbert, N. Sauvonnet, A. Dautry-Varsat
    Pages 119-148
  6. S. Sigismund, S. Polo, P. P. Di Fiore
    Pages 149-185
  7. Back Matter
    Pages 187-190

About this book

Introduction

This book reviews knowledge on the interconnection of signal transduction and endocytosis/intracellular trafficking. The chapters cover knowledge obtained by using different model systems. The first chapter deals with Receptor Tyrosin Kinases (RTKs) with emphasis on the Epidermal Growth Factor Receptor (EGF receptor) and the Platelet Derived Growth Factor Receptor (PDGF receptor). The second chapter deals with the RTK c-Met and with how this RTK becomes carcinogenic. The third chapter reviews recent understanding on the mechanisms of action of the numerous fibroblast growth factors and their receptors. In the fourth chapter we learn about the trafficking of and signalling from the Growth Hormone Receptor and how this receptor is controlled by ubiquitination. The fifth chapter is devoted to the Interleukin II receptor, essential for activation of T cells. Links between ubiquitination, signalling, endocytosis, and sorting are reviewed. The last chapter discusses current views on how monoubiquitination controls both signalling and trafficking and thereby the final outcome of receptor activation.

Keywords

Cellular microenvironments Endocytosis Growth factor Intracellular trafficking Signal transduction regulation

Editors and affiliations

  • Inger Helene Madshus
    • 1
  1. 1.Institute of PathologyRikshospitalet University HospitalOsloNorway

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-540-69494-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 2004
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-05912-4
  • Online ISBN 978-3-540-69494-6
  • Series Print ISSN 0070-217X
  • About this book