Cell and Tissue Reaction Engineering

With a Contribution by Martin Fussenegger and Wilfried Weber

  • Regine Eibl
  • Dieter Eibl
  • Ralf Pörtner
  • Gerardo Catapano
  • Peter Czermak

Part of the Principles and Practice book series (PRINCIPLES)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Mammalian Cells

    1. D. Eibl, R. Eibl, R. Pörtner
      Pages 3-11
    2. P. Czermak, R. Pörtner, A. Brix
      Pages 83-172
    3. G. Catapano, P. Czermak, R. Eibl, D. Eibl, R. Pörtner
      Pages 173-259
  3. Special Applications

    1. W. Weber, M. Fussenegger
      Pages 263-277
    2. G. Catapano
      Pages 279-313
    3. R. Eibl, D. Eibl
      Pages 315-356
  4. Back Matter
    Pages 357-363

About this book


The completion of the Human Genome Project and the rapid progress in cell bi- ogy and biochemical engineering, are major forces driving the steady increase of approved biotech products, especially biopharmaceuticals, in the market. Today mammalian cell products (“products from cells”), primarily monoclonals, cytokines, recombinant glycoproteins, and, increasingly, vaccines, dominate the biopharmaceutical industry. Moreover, a small number of products consisting of in vitro cultivated cells (“cells as product”) for regenerative medicine have also been introduced in the market. Their efficient production requires comprehensive knowledge of biological as well as biochemical mammalian cell culture fundamentals (e.g., cell characteristics and metabolism, cell line establishment, culture medium optimization) and related engineering principles (e.g., bioreactor design, process scale-up and optimization). In addition, new developments focusing on cell line development, animal-free c- ture media, disposables and the implications of changing processes (multi-purpo- facilities) have to be taken into account. While a number of excellent books treating the basic methods and applications of mammalian cell culture technology have been published, only little attention has been afforded to their engineering aspects. The aim of this book is to make a contribution to closing this gap; it particularly focuses on the interactions between biological and biochemical and engineering principles in processes derived from cell cultures. It is not intended to give a c- prehensive overview of the literature. This has been done extensively elsewhere.


Bioprozesstechnik Bioreaktor Fermentation bioprocess engineering bioreactor biotechnology cell culture cells glycoprotein protein proteins reaction regenerative medicine tissue tissue engineering

Authors and affiliations

  • Regine Eibl
    • 1
  • Dieter Eibl
    • 1
  • Ralf Pörtner
    • 2
  • Gerardo Catapano
    • 3
  • Peter Czermak
    • 4
    • 5
  1. 1.Department for Life Sciences and Facility ManagementInstitute for Biotechnology Zurich University of Applied SciencesWädenswilSwitzerland
  2. 2.Institute for Bioprocess and Biosystems EngineeringHamburg University of Technology (TUHH)HamburgGermany
  3. 3.Department of Chemical Engineering and MaterialsUniversity of CalabriaRende (CS)Italy
  4. 4.Institute of Biopharmaceutical TechnologyUniversity of Applied Sciences Giessen-FriedbergGiessenGermany
  5. 5.Department of Chemical EngineeringKansas State UniversityManhattanUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2009
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-68175-5
  • Online ISBN 978-3-540-68182-3
  • Series Print ISSN 1866-914X
  • Buy this book on publisher's site