Differentiation and Neoplasia

  • Robert G. McKinnell
  • Marie A. DiBerardino
  • Martin Blumenfeld
  • Robert D. Bergad

Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 11)

Table of contents

  1. Front Matter
    Pages I-XVI
  2. D. A. Melton, R. Cortese, E. M. de Robertis, M. F. Trendelenburg, J. B. Gurdon
    Pages 8-14
  3. W. W. Franke, U. Scheer, H. Zentgraf, M. F. Trendelenburg, U. Müller, G. Krohne et al.
    Pages 15-36
  4. K. Martin, Y. N. Osheim, A. L. Beyer, O. L. Miller Jr.
    Pages 37-44
  5. M. Blumenfeld, P. C. Billings, J. W. Orf, C. G. Pan, D. K. Palmer, L. A. Snyder
    Pages 45-48
  6. D. E. Comings, T. A. Okada
    Pages 49-52
  7. P. C. Nowell
    Pages 102-106
  8. R. Kemler, D. Morello, Ch. Babinet, F. Jacob
    Pages 107-111
  9. B. R. Brinkley, L. J. Wible, B. B. Asch, D. Medina, M. M. Mace, P. T. Beall et al.
    Pages 132-138
  10. Nelson Tracy Spratt Jr., Ross L. Shoger
    Pages 155-156
  11. H. Holtzer, J. Biehl, M. Pacifici, D. Boettiger, R. Payette, C. West
    Pages 166-177
  12. H. M. Temin
    Pages 196-201
  13. E. A. McCulloch, R. N. Buick, M. D. Minden, C. A. Izaguirre
    Pages 217-227
  14. A. M. Mauer, S. B. Murphy, F. A. Hayes
    Pages 228-232
  15. E. Gorelik, M. Fogel, S. Segal, M. Feldman
    Pages 233-240
  16. H. C. Pitot, A. E. Sirica
    Pages 241-250
  17. M. J. Dewey, B. Mintz
    Pages 275-282
  18. N. Škreb, V. Crnek
    Pages 283-289
  19. B. J. Kennedy
    Pages 298-303
  20. Back Matter
    Pages 305-312

About this book


There is no commonly accepted mechanism to explain differentiation of either normal or neoplastic cells. Despite this fact, the organizers of the 3 rd International Conference on Differentiation recognized that there is much emerging evidence which supports the view that both normal cells and many cancer cells share common differentiative processes. Accordingly, the organizers perceived that clinical scientists and developmental biologists would greatly benefit by together considering differentiation. In that way, developmental biologists would be apprised of recent insights in cancer cell biology and the physician scientist would be updated on events in developmental biology and both would gain new understanding of the cell biology of neoplasia. A specific example may reveal the potential value of developmental biologists interacting with cancer physicians. An example chosen at random suggests that probably any paper included in the symposium volume would serve the purpose. Dr. Stephen Subtelny reviewed recent studies by his laboratory concerning germ cell migration and replication in frog embryos. How might those results interest the cancer scientist? Dr. Subtelny showed that primordial germ cells of a fertile graft will reverse their migratory direction and move into a sterile host. Perhaps in this context it would not be inappropriate to state that the germ cells of the graft metastasized into the host. Germ cells from grafts of a different species will populate the previously sterile host gonad.


Cytoplasmic effects Krebs Neoplasia Oncology Tumor Zelldifferenzierung cell biology developmental biology migration

Editors and affiliations

  • Robert G. McKinnell
    • 1
  • Marie A. DiBerardino
    • 2
  • Martin Blumenfeld
    • 3
  • Robert D. Bergad
    • 3
  1. 1.Department of Genetics and Cell BiologyUniversity of MinnesotaSt. PaulUSA
  2. 2.Department of AnatomyMedical College of PennsylvaniaPhiladelphiaUSA
  3. 3.Department of Genetics and Cell BiologyUniversity of MinnesotaSt. PaulUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1980
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-662-11561-9
  • Online ISBN 978-3-540-38267-6
  • Series Print ISSN 0080-1844
  • Series Online ISSN 1861-0412
  • Buy this book on publisher's site