Alzheimer: 100 Years and Beyond

ISBN: 978-3-540-37651-4 (Print) 978-3-540-37652-1 (Online)

Table of contents (59 chapters)

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  1. Front Matter

    Pages I-XXXIII

  2. Alois Alzheimer

    1. Front Matter

      Pages 1-1

    2. No Access

      Chapter

      Pages 3-11

      Concerning a unique disease of the cerebral cortex

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      Chapter

      Pages 13-34

      The history of Alois Alzheimer’s first case Auguste D.

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      Chapter

      Pages 37-49

      Alois Alzheimer and the beginnings of research into Alzheimer’s disease

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      Chapter

      Pages 51-55

      Alois Alzheimer and the myth of the pioneer

  3. The beginning of modern research

    1. Front Matter

      Pages 57-57

    2. No Access

      Chapter

      Pages 59-61

      Alzheimer’s Disease at mid-Century (1927–1977) and a little more

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      Chapter

      Pages 63-86

      A chapter in the development on Alzheimer’s disease research

  4. Anatomy & Neuropsychology

    1. Front Matter

      Pages 87-87

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      Chapter

      Pages 89-94

      Anatomical changes underlying dementia in Alzheimer’s disease

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      Chapter

      Pages 97-106

      Staging of cortical neurofibrillary inclusions of the Alzheimer’s type

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      Chapter

      Pages 109-113

      Of stains and brains: a brief account of how microscopic and clinical observations contributed to the understanding of Alzheimer’s disease

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      Chapter

      Pages 115-119

      Presenile forms of Alzheimer’s disease in 2006

  5. Cholinergic Deficit

    1. Front Matter

      Pages 121-121

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      Chapter

      Pages 123-125

      The cholinergic deficit in Alzheimer’s disease

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      Chapter

      Pages 127-132

      Acetylcholine in AD: Expectations meet reality

  6. Amyloid and Genetics

    1. Front Matter

      Pages 133-133

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      Chapter

      Pages 135-140

      The Discovery of β Amyloid

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      Chapter

      Pages 143-149

      Pathways to the discovery of the neuronal origin and proteolytic biogenesis of Aβ amyloid of Alzheimer’s disease

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      Chapter

      Pages 151-154

      The Amyloid Hypothesis: history and alternatives

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      Chapter

      Pages 157-161

      Segregation of a missense mutation in the amyloid β-protein precursor gene with familial Alzheimer’s disease

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      Chapter

      Pages 163-169

      From the amyloid β protein (A4) to isolation of the first Alzheimer’s disease gene: amyloid β (A4) precursor protein (APP)

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      Chapter

      Pages 171-172

      Commentary on “Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice”

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      Chapter

      Pages 175-186

      Vision for the future

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      Chapter

      Pages 189-195

      PS1, PS2, and APP mutations that cause Alzheimer’s disease increase Aβ42

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