Advertisement

Left-Right Asymmetry in Vertebrate Development

  • Maria L. López-Gracia
  • Marian Ros

Part of the Advances in Anatomy Embryology and Cell Biology book series (ADVSANAT, volume 188)

Table of contents

About this book

Introduction

Externally the vertebrate body plan presents a bilateral symmetry in relation to the midline. However, inside the body the distribution of the visceral organs follows a very particular pattern that is not symmetrical in relation to the midline. The last 10 years have seen remarkable advances in our understanding of how the internal asymmetries typical of the vertebrate body are established and controlled. The use of different development models has permitted to uncover fascinating ways of creating asymmetry, like the activity of the nodal cilia. A host of studies has also unravelled the involvement of many genes in the left right patterning pathway. Based on this knowledge the genetic basis of human laterality defects are beginning to be revealed. It is a major challenge now to understand how all these genes control left right development as well as the complex set of interactions established between them.

Keywords

Kartagener development heart development heterotaxia left-right axis left-right patterning primary ciliary dyskinesia, PCD situs ambiguus situs inversus

Authors and affiliations

  • Maria L. López-Gracia
    • 1
  • Marian Ros
    • 1
  1. 1.Departamento de Anatomía y Biología Celular, Faculdad de MedicinaUniversidad de CantabriaSantanderSpain

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-540-36348-4
  • Copyright Information Springer-Verlag Berlin Heidelberg 2007
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-36347-7
  • Online ISBN 978-3-540-36348-4
  • Series Print ISSN 0301-5556
  • Buy this book on publisher's site