Structural Approaches to Sequence Evolution

Molecules, Networks, Populations

  • Ugo Bastolla
  • Markus Porto
  • H. Eduardo Roman
  • Michele Vendruscolo

Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

Table of contents

  1. Front Matter
    Pages I-XIX
  2. Molecules: Proteins and RNA

    1. Front Matter
      Pages 1-1
    2. Juan Garcia Ranea, Corin Yeats, Russell Marsden, Christine Orengo
      Pages 37-55
    3. Ugo Bastolla, Markus Porto, H. Eduardo Roman, Michele Vendruscolo
      Pages 75-112
    4. Nikolay V. Dokholyan, Eugene I. Shakhnovich
      Pages 113-126
  3. Molecules: Genomes

    1. Front Matter
      Pages 128-128
    2. Francisco J. Silva, Amparo Latorre, Laura Gómez-Valero, Andres Moya
      Pages 149-165
  4. Phylogenetic Analysis

  5. Networks

    1. Front Matter
      Pages 234-234
    2. I. King Jordan, Leonardo Mariñno-Ramírez
      Pages 235-252
  6. Populations

  7. Back Matter
    Pages 363-367

About this book


Structural requirements constrain the evolution of biological entities at all levels, from macromolecules to their networks, right up to populations of biological organisms. Classical models of molecular evolution, however, are focused at the level of the symbols - the biological sequence - rather than that of their resulting structure. Now recent advances in understanding the thermodynamics of macromolecules, the topological properties of gene networks, the organization and mutation capabilities of genomes, and the structure of populations make it possible to incorporate these key elements into a broader and deeply interdisciplinary view of molecular evolution. This book gives an account of such a new approach, through clear tutorial contributions by leading scientists specializing in the different fields involved.


DNA biology biophysics computational biology evolution gene expression genes genetic engineering genetics genome genomics molecular evolution population protein thermodynamics

Editors and affiliations

  • Ugo Bastolla
    • 1
  • Markus Porto
    • 2
  • H. Eduardo Roman
    • 3
  • Michele Vendruscolo
    • 4
  1. 1.Fac. de CienciasUniversidad Autonoma MadridMadridSpain
  2. 2.Institut für FestkörperphysikTU DarmstadtDarmstadtGermany
  3. 3.Dipartimento di FisicaUniversita di Milano-BicoccaMilanoItaly
  4. 4.Department of ChemistryUniversity of CambridgeCambridgeUK

Bibliographic information