Hippocampal Microcircuits

A Computational Modeler's Resource Book

  • Vassilis Cutsuridis
  • Bruce P. Graham
  • Stuart Cobb
  • Imre Vida

Part of the Springer Series in Computational Neuroscience book series (NEUROSCI)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Part I

    1. Front Matter
      Pages 1-3
    2. Menno P. Witter
      Pages 5-28
    3. Imre Vida, Claudius E. Degro, Sam A. Booker
      Pages 29-90
    4. Marco Martina, Cheng-Chang Lien
      Pages 91-126
    5. Marlene Bartos, Jonas-Frederic Sauer, Imre Vida, Ákos Kulik
      Pages 159-200
    6. J. Josh Lawrence, Stuart Cobb
      Pages 227-325
    7. Tengis Gloveli, Sam A. Booker, Nancy Kopell, Tamar Dugladze
      Pages 327-364
  3. Part II

    1. Front Matter
      Pages 437-440
    2. Keivan Moradi, Giorgio A. Ascoli
      Pages 441-471
    3. Henrik Lindén, Tom Tetzlaff, Szymon Łeski, Klas H. Pettersen, Sonja Grün, Markus Diesmann et al.
      Pages 509-533
    4. Daniel Bush, Christoph Schmidt-Hieber
      Pages 585-613
    5. Michael Graupner, Nicolas Brunel
      Pages 615-644
    6. Ausra Saudargiene, Bruce P. Graham
      Pages 669-700
    7. Azam Shirrafiardekani, Jörg Frauendiener, Ahmed A. Moustafa, Lubica Benuskova
      Pages 701-737
    8. Samuel A. Neymotin, Nathan S. Kline, Mohamed A. Sherif, Jeeyune Q. Jung, Joseph J. Kabariti, William W. Lytton
      Pages 739-756
    9. Sanjay M., Srinivasa B. Krothapalli
      Pages 757-777
    10. Justas Birgiolas, Sharon M. Crook, Richard C. Gerkin
      Pages 807-830
  4. Sanjay M., Srinivasa B. Krothapalli
    Pages C1-C1
  5. Azam Shirrafiardekani, Jörg Frauendiener, Ahmed A. Moustafa, Lubica Benuskova
    Pages C3-C3
  6. Back Matter
    Pages 867-885

About this book


This is the 2nd edition of a very well received and popular book that reflects the current state-of-the-art of the ongoing research avenues concerning the hippocampus and processing units bridging the gap between single cell activity, network activity and global brain function. It aims to provide a methodology to anyone interested in developing microcircuit level models of the hippocampus.

The book is divided into two thematic areas: (I) Experimental background and (II) Computational analysis. In part I, leading experimental neuroscientists discuss the morphological, physiological and molecular characteristics as well as the connectivity and synaptic properties of the various cell types found in the hippocampus. Behaviour-related ensemble activity patterns of morphologically identified neurons in anesthetized and freely moving animals provide insights on the function of the hippocampal areas. In part II, computational neuroscientists present models of the hippocampal microcircuits at various levels of detail (e.g. single cell level, network level, etc.). Synaptomics and connectomics models of hippocampal structures are initially discussed. Then, network models of memory, rhythm generation and spatial navigation are presented, followed by abstract and biophysical models of synaptic plasticity. Network models of hippocampal implicated disorders (epilepsy and schizophrenia) are then detailed and how their network topologies, connectivities and activities change in these diseases. Finally, two chapters are dedicated to describing simulator environments of single neurons and networks currently used by computational neuroscientists in developing their models and modelling tools to parametrically constrain them.     

This engaging volume is invaluable to experimental and computational neuroscientists, electrical engineers, physicists, mathematicians and others interested in developing microcircuit models of the hippocampus. Graduate level students and trainees in all of these fields can find this book a significant source of information.


Cortex Radiologieinformationssystem anatomy behavior computational neuroscience declarative memories hippocampus microcircuits neurons physiology synaptic properties

Editors and affiliations

  • Vassilis Cutsuridis
    • 1
  • Bruce P. Graham
    • 2
  • Stuart Cobb
    • 3
  • Imre Vida
    • 4
  1. 1.School of Computer ScienceUniversity of LincolnLincolnUK
  2. 2.School of Natural Sciences, Department of Computing Science and MathematicsUniversity of StirlingStirlingUK
  3. 3.Centre for Discovery Brain SciencesUniversity of EdinburghEdinburghUK
  4. 4.Institute for Integrative NeuroanatomyCharité – Universitätsmedizin BerlinBerlinGermany

Bibliographic information