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Radiopharmaceutical Chemistry

  • Jason S. Lewis
  • Albert D. Windhorst
  • Brian M. Zeglis

Table of contents

  1. Front Matter
    Pages i-xviii
  2. First Principles

    1. Front Matter
      Pages 1-1
    2. David Mankoff
      Pages 3-10
    3. Carolyn J. Anderson, Xiaoxi Ling, David J. Schlyer, Cathy S. Cutler
      Pages 11-26
    4. Lauren L. Radford, Suzanne E. Lapi
      Pages 63-83
    5. Michal Grzmil, Alexander Meisel, Martin Behé, Roger Schibli
      Pages 85-100
    6. Pat Zanzonico
      Pages 101-117
    7. Antony D. Gee, Salvatore Bongarzone, Alan A. Wilson
      Pages 119-136
    8. Ryan A. Davis, Sven H. Hausner, Julie L. Sutcliffe
      Pages 137-162
    9. Danielle J. Vugts, Guus A. M. S. van Dongen
      Pages 163-179
    10. Anyanee Kamkaew, Emily B. Ehlerding, Weibo Cai
      Pages 181-203
  3. Radiochemistry

    1. Front Matter
      Pages 205-205
    2. Verena Pichler, Neydher Berroterán-Infante, Marius Ozenil, Sarah Pfaff, Cécile Philippe, Wolfgang Wadsak
      Pages 221-236
    3. Vanessa Gómez-Vallejo, Luka Rejc, Fernando López-Gallego, Jordi Llop
      Pages 237-254
    4. Julia E. Blower, Maggie S. Cooper, Cinzia Imberti, Michelle T. Ma, Christopher Marshall, Jennifer D. Young et al.
      Pages 255-271
    5. Stephanie M. Rathmann, Zainab Ahmad, Samantha Slikboer, Holly A. Bilton, Denis P. Snider, John F. Valliant
      Pages 311-333
    6. Xiaoxi Ling, Cathy S. Cutler, Carolyn J. Anderson
      Pages 335-358
    7. Elaheh Khozeimeh Sarbisheh, Eric W. Price
      Pages 359-370
    8. Bernadette V. Marquez-Nostra, Nerissa Viola
      Pages 371-390
    9. Ganesan Vaidyanathan, Michael R. Zalutsky
      Pages 391-408
  4. Special Topics

    1. Front Matter
      Pages 447-447
    2. Jens Cardinale, Carolina Giammei, Nedra Jouini, Thomas L. Mindt
      Pages 449-466
    3. James C. Knight, Bart Cornelissen
      Pages 467-479
    4. Stephen Thompson, Peter J. H. Scott
      Pages 481-499
    5. Mark Lubberink, Kerstin Heurling
      Pages 501-514
    6. Brian Serencsits, Brian M. Quinn, Lawrence T. Dauer
      Pages 515-529
    7. Kristen M. Cunanan, Mithat Gönen
      Pages 531-539
    8. Andrew M. Scott, Yit Wooi Goh, Sze Ting Lee, Salvatore U. Berlangieri
      Pages 541-553
    9. Julien Dimastromatteo, Kimberly A. Kelly
      Pages 555-567
    10. Sridhar Nimmagadda, Sagar Shelake, Martin G. Pomper
      Pages 569-582
    11. Kristina Herfert, Sabina Marciano, Laura Kuebler, Sabrina Buss, Natalie Landeck, Julia G. Mannheim et al.
      Pages 583-606
    12. Iván Peñuelas, Philip H. Elsinga
      Pages 607-618
    13. Sonia Sequeira, Serge K. Lyashchenko
      Pages 619-625
    14. Ashley Mishoe, Phillip DeNoble
      Pages 627-633
  5. Back Matter
    Pages 635-651

About this book

Introduction

This book is a comprehensive guide to radiopharmaceutical chemistry. The stunning clinical successes of nuclear imaging and targeted radiotherapy have resulted in rapid growth in the field of radiopharmaceutical chemistry, an essential component of nuclear medicine and radiology. However, at this point, interest in the field outpaces the academic and educational infrastructure needed to train radiopharmaceutical chemists. For example, the vast majority of texts that address radiopharmaceutical chemistry do so only peripherally, focusing instead on nuclear chemistry (i.e. nuclear reactions in reactors), heavy element radiochemistry (i.e. the decomposition of radioactive waste), or solely on the clinical applications of radiopharmaceuticals (e.g. the use of PET tracers in oncology). This text fills that gap by focusing on the chemistry of radiopharmaceuticals, with key coverage of how that knowledge translates to the development of diagnostic and therapeutic radiopharmaceuticals for the clinic.

 

The text is divided into three overarching sections: First Principles, Radiochemistry, and Special Topics. The first is a general overview covering fundamental and broad issues like “The Production of Radionuclides” and “Basics of Radiochemistry”. The second section is the main focus of the book. In this section, each chapter’s author will delve much deeper into the subject matter, covering both well established and state-of-the-art techniques in radiopharmaceutical chemistry. This section will be divided according to radionuclide and will include chapters on radiolabeling methods using all of the common nuclides employed in radiopharmaceuticals, including four chapters on the ubiquitously used fluorine-18 and a “Best of the Rest” chapter to cover emerging radionuclides. Finally, the third section of the book is dedicated to special topics with important information for radiochemists, including “Bioconjugation Methods,” “Click Chemistry in Radiochemistry”, and “Radiochemical Instrumentation.”

 

This is an ideal educational guide for nuclear medicine physicians, radiologists, and radiopharmaceutical chemists, as well as residents and trainees in all of these areas.

Keywords

radiopharmaceutical chemistry radiochemistry PET SPECT radiotherapy nuclear imaging

Editors and affiliations

  • Jason S. Lewis
    • 1
  • Albert D. Windhorst
    • 2
  • Brian M. Zeglis
    • 3
  1. 1.Department of RadiologyMemorial Sloan Kettering Cancer CenterNew YorkUSA
  2. 2.Department of Radiology and Nuclear MedicineVU University Medical CenterAmsterdamThe Netherlands
  3. 3.Department of ChemistryHunter College, City University of New YorkNew YorkUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-98947-1
  • Copyright Information Springer Nature Switzerland AG 2019
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-98946-4
  • Online ISBN 978-3-319-98947-1
  • Buy this book on publisher's site