Textbook of Autoinflammation

  • Philip J. Hashkes
  • Ronald M. Laxer
  • Anna Simon

Table of contents

  1. Front Matter
    Pages i-x
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Daniel L. Kastner
      Pages 3-15
  3. Basic Science and Biology of Autoinflammation

    1. Front Matter
      Pages 17-17
    2. Isabella Ceccherini, Marta Rusmini, Juan Ignacio Arostegui
      Pages 19-48
    3. Clara Lorente-Sorolla, Mihai G. Netea, Esteban Ballestar
      Pages 49-60
    4. Victor Saavedra, Fiona Moghaddas, Eicke Latz, Seth L. Masters
      Pages 61-87
    5. Lori Broderick
      Pages 89-109
    6. Angela Rösen-Wolff, Anna Rubartelli
      Pages 111-122
    7. Anja Brehm, Frédéric Ebstein, Elke Krüger
      Pages 123-136
    8. Dirk Holzinger, Christoph Kessel, Dirk Foell
      Pages 149-163
  4. General Approach to Autoinflammatory Diseases

    1. Front Matter
      Pages 165-165
    2. Raphaela Goldbach-Mansky, Adriana A. de Jesus
      Pages 167-201
    3. Philip J. Hashkes, Karyl S. Barron, Ronald M. Laxer
      Pages 203-223
    4. Isabelle Touitou, Ivona Aksentijevich
      Pages 225-237
    5. Nienke ter Haar, Maryam Piram, Isabelle Koné-Paut
      Pages 239-252
    6. Martina Finetti, Marco Gattorno
      Pages 253-265
    7. Tamer Rezk, Philip N. Hawkins
      Pages 267-289
  5. Monogenic Autoinflammatory Diseases

    1. Front Matter
      Pages 291-291
    2. Shai Padeh, Yelda Bilginer, Seza Ozen
      Pages 293-313
    3. Joost Frenkel, Anna Simon
      Pages 315-327
    4. Sinisa Savic, Michael F. McDermott
      Pages 329-345
    5. Hal M. Hoffman, Jasmin B. Kuemmerle-Deschner, Raphaela Goldbach-Mansky
      Pages 347-365
    6. Carlos D. Rose, Carine H. Wouters
      Pages 367-381
    7. Marilynn G. Punaro, Carol A. Wise
      Pages 405-415
    8. Amanda Ombrello, Reeval Segel
      Pages 417-431
    9. Despina Eleftheriou, Antonio Torrelo, Paul A. Brogan
      Pages 433-453
    10. James Verbsky, Polly J. Ferguson
      Pages 455-470
    11. Satveer K. Mahil, Jonathan N. Barker, Francesca Capon
      Pages 471-484
    12. Ngoc Minh Phuong Nguyen, Pierre-Adrien Bolze, Rima Slim
      Pages 485-497
    13. Isabelle Jéru, Scott W. Canna, Eric P. Hanson
      Pages 515-538
  6. Complex Autoinflammatory Diseases

    1. Front Matter
      Pages 539-539
    2. Christian M. Hedrich, Hermann J. Girschick
      Pages 563-585
    3. Peter A. Nigrovic, Rayfel Schneider
      Pages 587-616
    4. Alexei A. Grom, Edward M. Behrens
      Pages 617-633
    5. Naomi Schlesinger, Johnson C. Kay
      Pages 635-645
    6. Ahmet Gül
      Pages 647-665
    7. Massimo Imazio, Anna Valenti, Antonio Brucato, Alberto Martini
      Pages 667-677
    8. Heleen D. de Koning, Karoline Krause
      Pages 679-689
  7. The Relationship Between Autoinflammation and Other Inflammatory and Common Diseases

    1. Front Matter
      Pages 691-691
    2. Dennis McGonagle, Abdulla Watad
      Pages 693-710
  8. Pharmaceutical Agents for Treatment of the Autoinflammatory Diseases

    1. Front Matter
      Pages 727-727
    2. Eldad Ben-Chetrit
      Pages 729-749
    3. Tilmann Kallinich, Fabrizio de Benedetti
      Pages 751-774

About this book


This book, the first complete textbook on this novel field in Medicine, comprehensively covers the clinical presentation, pathogenesis, genetics, and latest management strategies for autoinflammatory disorders as well as the basic science of autoinflammation. Relevant concepts such as how translational science of genetics and immunology relates to the innate immune system and autoinflammation are covered. Descriptions of the monogenic and polygenic/complex diseases that fall under the umbrella of autoinflammatory diseases are provided. Further topics covered include the latest clinical and genetic diagnostic approaches, concepts on the relationship between autoinflammation and autoimmunity/immunodeficiency, the role of autoinflammation in cancer, treatments and management strategies for these diseases, and potential areas of future development. 

The Textbook of Autoinflammation systematically describes and reviews diagnostic and treatment options for autoinflammatory disorders as well as all aspects of the concept of autoinflammation, and represents a valuable resource for professionals in a variety of disciplines who encounter these patients or who study autoinflammation.


Immunology Diabetes Genetics Immune System Clinical Features Immunodeficiency

Editors and affiliations

  • Philip J. Hashkes
    • 1
  • Ronald M. Laxer
    • 2
  • Anna Simon
    • 3
  1. 1.Pediatric Rheumatology UnitShaare Zedek Medical Center and Hebrew UniversityJerusalemIsrael
  2. 2.Department Paediatrics, Division of RheumatologyThe Hospital for Sick Children and University of TorontoTorontoCanada
  3. 3.Department of Internal MedicineRadboudumc Expertisecenter for Immunodeficiency and Autoinflammation, Radboud University Medical CenterNijmegenThe Netherlands

Bibliographic information