Regenerative Medicine and Stem Cell Therapy for the Eye

  • Brian G. Ballios
  • Michael J. Young

Part of the Fundamental Biomedical Technologies book series (FBMT)

Table of contents

  1. Front Matter
    Pages i-x
  2. Akshayalakshmi Sridhar, Kirstin B. Langer, Clarisse M. Fligor, Matthew Steinhart, Casey A. Miller, Kimberly T. Ho-A-Lim et al.
    Pages 17-49
  3. Linyang Yu, Vianney Delplace, Samantha L. Payne, Molly S. Shoichet
    Pages 51-86
  4. Michael J. Young, Jea Young Park
    Pages 87-122
  5. Bruce R. Ksander, Markus H. Frank, Natasha Y. Frank
    Pages 123-148
  6. Christopher D. McTiernan, Isabelle Brunette, May Griffith
    Pages 149-171
  7. Brian G. Ballios, Allan R. Slomovic
    Pages 173-191
  8. Petr Baranov, Julia Oswald
    Pages 193-206
  9. Back Matter
    Pages 207-212

About this book


This book provides an overview of the types, sources, and applications of stem cells in regenerating various ocular tissues, with a perspective on both potential applications of stem cells and possible challenges. The scope of the chapters include both preclinical and clinical applications, including stem cell-derived therapies based on endogenous tissue repair; stem cell transplantation  and cell replacement therapy; gene therapy; and in vitro disease modelling.  Additionally, the volume presents applications in both anterior and posterior ocular disease, with a particular focus on diseases of the ocular surface, cornea, limbus, and retina, including inherited retinal dystrophies as well as acquired diseases, such as age-related macular degeneration. Regenerative Medicine and Stem Cell Therapy for the Eye is an ideal book for advanced researchers in stem cell and ocular biology as well as clinical ophthalmologists, and will be of interest to readers with backgrounds in developmental biology and bioengineering.   

This book also

  • Skillfully reviews cutting-edge advances in stem cell biology as applied to regenerative medicine and ocular disease
  • Provides expert viewpoints on key hurdles and challenges to successful implementation of stem cell-derived therapies in the clinical domain
  • Offers a multi-disciplinary, broad understanding of cell-based therapies for ocular diseases by incorporating perspectives from biomedical scientists, physicians, and engineers
  • Examines the connection between cell therapy and gene editing, in particular relation to ocular disease


retinal regeneration ocular surface stem cell transplantation photoreceptors transplantation retinal pigment epithelium transplantation retinal stem cells limbal stem cells embryonic stem cells induced-pluripotent stem cells

Editors and affiliations

  • Brian G. Ballios
    • 1
  • Michael J. Young
    • 2
  1. 1.Department Ophthalmology and Vision SciencesUniversity of TorontoTorontoCanada
  2. 2.Schepens Eye Research InstituteHarvard Medical SchoolBostonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Switzerland AG 2018
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-98079-9
  • Online ISBN 978-3-319-98080-5
  • Series Print ISSN 1559-7083
  • Series Online ISSN 2626-8655
  • Buy this book on publisher's site