Cardiac Extracellular Matrix

Fundamental Science to Clinical Applications

  • Eric G. Schmuck
  • Peiman Hematti
  • Amish N. Raval

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1098)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Michael Nguyen-Truong, Zhijie Wang
    Pages 1-19
  3. Michael A. Pinkert, Rebecca A. Hortensius, Brenda M. Ogle, Kevin W. Eliceiri
    Pages 21-44
  4. Mark C. Daley, Spencer L. Fenn, Lauren D. Black III
    Pages 59-83
  5. Karis R. Tang-Quan, Nicole A. Mehta, Luiz C. Sampaio, Doris A. Taylor
    Pages 85-114
  6. Keith L. Spinali, Eric G. Schmuck
    Pages 115-130
  7. Mikayla L. Hall, Brenda M. Ogle
    Pages 131-150
  8. Jenna L. Dziki, Stephen F. Badylak
    Pages 151-171
  9. Adrian P. Gee
    Pages 189-198
  10. Back Matter
    Pages 237-246

About this book


This book on cardiac extracellular matrix (ECM) features three sections, Fundamental Science, Pre-Clinical and Translational Science, and Clinical Applications. In the Fundamental Science section, we will cover the spectrum of basic ECM science from ECM’s role in development, biomechanical properties, cardiac ECM influence of cardiomyocyte biology, pathophysiology of ECM in heart disease, and ECM in tissue engineering. Section two, Preclinical and Translational Science, will discuss cardiac ECM technologies in the clinical pipeline including approaches to ECM as a therapeutic, animal models of cardiac research, tracking and imaging methods of cardiac ECM, and cGMP manufacturing and regulatory considerations for ECM based therapeutics. Finally, the third section, Clinical Applications, will highlight the clinical experience around cardiac ECM including therapeutic strategies targeting scar tissue in the heart, Clinical trial design and regulatory considerations, current human clinical trials in cardiovascular medicine and the role of pharmaceutical and biotech companies in the commercialization of ECM technologies for cardiovascular indications. This book provides a comprehensive review for basic and translational researchers as well as clinical practitioners and those involved in commercialization, regulatory and entrepreneurial activities.


developmental biology cardiac medicine heart disease cellular therapies cardiac scar tissue

Editors and affiliations

  • Eric G. Schmuck
    • 1
  • Peiman Hematti
    • 2
  • Amish N. Raval
    • 3
  1. 1.School of Medicine & Public HealthUniversity of Wisconsin-MadisonMadisonUSA
  2. 2.School of Medicine & Public HealthUniversity of Wisconsin-MadisonMadisonUSA
  3. 3.School of Medicine & Public HealthUniversity of Wisconsin-MadisonMadisonUSA

Bibliographic information