Molecular Diagnostics in Cytopathology

A Practical Handbook for the Practicing Pathologist

  • Sinchita Roy-Chowdhuri
  • Paul A. VanderLaan
  • John M. Stewart
  • Gilda da Cunha Santos

Table of contents

  1. Front Matter
    Pages i-xv
  2. Overview of Molecular Cytopathology

    1. Front Matter
      Pages 1-1
  3. Laboratory Processing: Practical Considerations

    1. Front Matter
      Pages 21-21
    2. Gilda da Cunha Santos, Mauro Ajaj Saieg
      Pages 23-38
    3. Ross A. Miller, Ashwyna Sunassee
      Pages 39-60
    4. John M. Stewart
      Pages 61-81
    5. Pasquale Pisapia, Miriam Cieri, Francesco Pepe, Umberto Malapelle, Giancarlo Troncone
      Pages 83-97
    6. Umberto Malapelle, Pasquale Pisapia, Miriam Cieri, Francesco Pepe, Giancarlo Troncone
      Pages 99-119
    7. Karen D. Tsuchiya, Laura J. Tafe, Julia A. Bridge
      Pages 121-159
  4. Clinical Relevance

    1. Front Matter
      Pages 179-179
    2. Eleanor Russell-Goldman, Jeffrey F. Krane
      Pages 181-197
    3. Paul A. VanderLaan
      Pages 223-247
    4. Michiya Nishino
      Pages 249-299
    5. Liza M. Quintana
      Pages 301-336
    6. Esther Diana Rossi, Zubair W. Baloch
      Pages 337-353
    7. Mingjuan Lisa Zhang, Martha Bishop Pitman
      Pages 355-376
    8. Güliz A. Barkan, Stefan E. Pambuccian
      Pages 377-403
    9. Rashmi Kanagal-Shamanna
      Pages 405-424
    10. Vickie Y. Jo, Xiaohua Qian
      Pages 425-489
    11. Maren Y. Fuller, Sara E. Monaco
      Pages 491-515
  5. Back Matter
    Pages 529-534

About this book


The main focus of this book is to provide an overview of the principles of molecular diagnostics in context of cytopathology specimens together with a basic understanding and working knowledge of the available technology, platforms, and clinical applications. The initial sections of the book summarize the pre-analytic aspects of molecular testing, including cytology specimen preparation and handling, specimen selection and evaluation, and workflow algorithms as well as the analytic considerations for a variety of nucleic acid and protein-based testing. The remaining section focuses on disease specific molecular testing for various organ-based applications. 

Molecular Diagnostics in Cytopathology: A Practical Handbook for the Practicing Pathologist serves as a useful resource for cytopathologists, surgical pathologists, molecular technologists, and all others dealing with the evolving field of molecular cytopathology. 


Solid organ malignancies cytology specimen Laboratory processing FISH assays RT-PCR assays Human papillomavirus

Editors and affiliations

  • Sinchita Roy-Chowdhuri
    • 1
  • Paul A. VanderLaan
    • 2
  • John M. Stewart
    • 3
  • Gilda da Cunha Santos
    • 4
  1. 1.MD Anderson Cancer CenterThe University of TexasHoustonUSA
  2. 2.Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonUSA
  3. 3.MD Anderson Cancer CenterThe University of TexasHoustonUSA
  4. 4.Department of Laboratory MedicineUniversity of TorontoTorontoCanada

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Switzerland AG 2019
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-97396-8
  • Online ISBN 978-3-319-97397-5
  • Buy this book on publisher's site