© 2019

The Papanicolaou Society of Cytopathology System for Reporting Respiratory Cytology

Definitions, Criteria, Explanatory Notes, and Recommendations for Ancillary Testing

  • Lester J. Layfield
  • Zubair Baloch

Table of contents

  1. Front Matter
    Pages i-ix
  2. Jalal B. Jalaly, Ioannis Ioannidis, Lester J. Layfield, Zubair Baloch
    Pages 1-6
  3. Lester J. Layfield, Zubair Baloch
    Pages 7-12
  4. Lester J. Layfield, Zubair Baloch
    Pages 13-26
  5. Gordon H. Yu
    Pages 27-39
  6. Lester J. Layfield, Zubair Baloch
    Pages 41-49
  7. Tamar C. Brandler, Andre Luis Moreira
    Pages 51-80
  8. Leslie G. Dodd, Allen Cole Burks
    Pages 81-94
  9. Lester J. Layfield, Esther Diana Rossi, Andre Luis Moreira, Zubair Baloch
    Pages 95-124
  10. Sinchita Roy-Chowdhuri, Nikoletta Sidiropoulos
    Pages 125-142
  11. Back Matter
    Pages 143-151

About this book


This text presents comprehensive review of the recommendations of the Papanicolaou Society of Cytopathology for reporting results of respiratory cytology specimens along with advances in diagnostic, prognostic, and predictive immunohistochemical and molecular techniques which can be performed on cytology specimens.The majority of the text focuses on the standardized terminology and nomenclature for respiratory cytology as recommended by the Papanicolaou Society of Cytopathology. Each of the diagnostic categories are described in depth and formal definitions for each category are given along with cytologic criteria. Explanatory notes are given discussing limitations of the category as well as its malignancy risk and reproducibility. Management recommendations are supplied for each category. Sample reports documenting the preferred reporting format are also given. Each category is associated with a reference list establishing the evidence based nature of the categories.

An in depth discussion of ancillary testing is provided, including the utilization of microbiologic culture, immunohistochemistry, and molecular techniques. Substantial emphasis is placed on molecular diagnostics necessary for optimization of personalized testing and the appropriate use of targeted therapies. The text represents a comprehensive resource for the state of the science of the cytologic diagnosis of respiratory lesions.


Ancillary Testing Diagnostic Terminology and Reporting microbiologic culture immunohistochemistry targeted therapies

Editors and affiliations

  • Lester J. Layfield
    • 1
  • Zubair Baloch
    • 2
  1. 1.Department of Pathology and Anatomical SciencesUniversity of MissouriColumbiaUSA
  2. 2.Department of Pathology and Laboratory MedicineHospital of the University of PennsylvaniaPhiladelphiaUSA

About the editors

Lester J. Layfield, MD

Professor and Chair

Department of Pathology & Anatomical Sciences

University of Missouri

One Hospital Drive

M263 Medical Sciences Building

Columbia, MO 


Zubair W. Baloch, MD, PhD. 

Hospital of the University of Pennsylvania, Perelman School of Medicine.

Department of Pathology & Laboratory Medicine

Philadelphia, PA 


Bibliographic information

  • Book Title The Papanicolaou Society of Cytopathology System for Reporting Respiratory Cytology
  • Book Subtitle Definitions, Criteria, Explanatory Notes, and Recommendations for Ancillary Testing
  • Editors Lester J. Layfield
    Zubair Baloch
  • DOI
  • Copyright Information Springer Nature Switzerland AG 2019
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Softcover ISBN 978-3-319-97234-3
  • eBook ISBN 978-3-319-97235-0
  • Edition Number 1
  • Number of Pages IX, 151
  • Number of Illustrations 0 b/w illustrations, 113 illustrations in colour
  • Topics Pathology
  • Buy this book on publisher's site


“All figures and tables are accompanied by useful legends. A very useful feature is the group of appendixes, which serves as a condensed version of the book and can be used for a quick lookup of criteria. As a book that aims to standardize respiratory cytology reporting, its ultimate success lies in the acceptance by practicing cytopathologists. … this book is a well‐written and much‐needed guideline from the Papanicolaou Society to further push for standardization of cytopathology reporting.” (Keluo Yao, Doody's Book Reviews, May 10, 2019)