© 2018


  • Bernhard Michalke

Part of the Molecular and Integrative Toxicology book series (MOLECUL)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Overview

    1. Front Matter
      Pages 1-1
    2. Regina Brigelius-Flohé
      Pages 3-26
  3. Bioaccessibility and Dietary Aspects of Selenium

    1. Front Matter
      Pages 27-27
    2. Philip J. White
      Pages 29-50
  4. Genes, Proteins, Pathways, and Metabolism Related to Selenium

    1. Front Matter
      Pages 69-69
    2. Caroline Vindry, Théophile Ohlmann, Laurent Chavatte
      Pages 89-107
  5. The Role of Selenium within Redox Systems, Inflammation, and Thyroid Interaction

    1. Front Matter
      Pages 109-109
    2. Solveigh C. Koeberle, Anna P. Kipp
      Pages 137-156
    3. Mara Ventura, Miguel Melo, Francisco Carrilho
      Pages 157-173
  6. The Role of Selenium in Neurodevelopment and Neurological Disorders

    1. Front Matter
      Pages 175-175
    2. Noelia Fradejas-Villar, Ulrich Schweizer
      Pages 177-192
    3. Anatoly V. Skalny, Margarita G. Skalnaya, Geir Bjørklund, Viktor A. Gritsenko, Jan Aaseth, Alexey A. Tinkov
      Pages 193-210
    4. Anatoly V. Skalny, Margarita G. Skalnaya, Lyudmila L. Klimenko, Aksana N. Mazilina, Alexey A. Tinkov
      Pages 211-230
    5. Tommaso Filippini, Bernhard Michalke, Jessica Mandrioli, Aristidis M. Tsatsakis, Jennifer Weuve, Marco Vinceti
      Pages 231-248
  7. The Role of Selenium in Cancer

    1. Front Matter
      Pages 249-249
    2. Arun Kumar Selvam, Mikael Björnstedt, Sougat Misra
      Pages 251-269

About this book


This book summarizes the fast-growing and current knowledge about selenium interaction with cancer, diabetes, neuro-degeneration, heart disease, muscle disorders, HIV and several more. A special focus will be placed on in-depth knowledge about gene expression, selenoprotein biosynthesis, seleno-metabolism--as well as the molecular pathways, physiological roles, and the molecular action of selenium including interaction with other elements and vitamins or as Se-nanoparticles. The reader will receive the newest information regarding redox status and redox regulatory systems, specifically in relation to different glutathione peroxidases and thioredoxin-reductases as well as about cellular bioavailability and cytotoxicity, de-balanced immune response, inflammation or dietary aspects.


selenium selenium and disease selenoproteins seleno-metabolism redox systems inflammatory mediators selenium toxicity

Editors and affiliations

  • Bernhard Michalke
    • 1
  1. 1.Research Unit: Analytical BioGeoChemistryHelmholtz Zentrum München – German Research Center for Environmental Health GmbHNeuherbergGermany

About the editors

Bernhard Michalke is head of the research group "Elements and Element Speciation" and of the "Central Inorganic Analysis Division" as well as deputy director of the research unit "Analytical BioGeoChemistry" at the Helmholtz Zentrum München - German Research Center for Environmental Health. He is also a lecturer at the Institute of Analytical Chemistry and Food Chemistry of the Technical University of Graz, Austria, which is where he received his habilitation in analytical chemistry. His research interests encompass speciation projects related to environmental health, i.e. the exposure and chemical speciation of neurodegenerative elements such as manganese, iron, copper or selenium and species-related neurotoxic effects in the central nervous system. He has published more than 200 peer reviewed articles and 10 book chapters. He has been and continues to be a co-organizer of several international conferences.

Bibliographic information


“The book provides up to date a comprehensive review of the hot topics in the field of Se research. It extends existing knowledge and brings new and valuable information for people working in science, clinic and industry.” (Jela Brozmanova, Neoplasma, Vol. 66 (4), 2019)