• Bernhard Michalke

Part of the Molecular and Integrative Toxicology book series (MOLECUL)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Overview

    1. Front Matter
      Pages 1-1
    2. Regina Brigelius-Flohé
      Pages 3-26
  3. Bioaccessibility and Dietary Aspects of Selenium

    1. Front Matter
      Pages 27-27
    2. Philip J. White
      Pages 29-50
  4. Genes, Proteins, Pathways, and Metabolism Related to Selenium

    1. Front Matter
      Pages 69-69
    2. Caroline Vindry, Théophile Ohlmann, Laurent Chavatte
      Pages 89-107
  5. The Role of Selenium within Redox Systems, Inflammation, and Thyroid Interaction

    1. Front Matter
      Pages 109-109
    2. Solveigh C. Koeberle, Anna P. Kipp
      Pages 137-156
    3. Mara Ventura, Miguel Melo, Francisco Carrilho
      Pages 157-173
  6. The Role of Selenium in Neurodevelopment and Neurological Disorders

    1. Front Matter
      Pages 175-175
    2. Noelia Fradejas-Villar, Ulrich Schweizer
      Pages 177-192
    3. Anatoly V. Skalny, Margarita G. Skalnaya, Geir Bjørklund, Viktor A. Gritsenko, Jan Aaseth, Alexey A. Tinkov
      Pages 193-210
    4. Anatoly V. Skalny, Margarita G. Skalnaya, Lyudmila L. Klimenko, Aksana N. Mazilina, Alexey A. Tinkov
      Pages 211-230
    5. Tommaso Filippini, Bernhard Michalke, Jessica Mandrioli, Aristidis M. Tsatsakis, Jennifer Weuve, Marco Vinceti
      Pages 231-248
  7. The Role of Selenium in Cancer

    1. Front Matter
      Pages 249-249
    2. Arun Kumar Selvam, Mikael Björnstedt, Sougat Misra
      Pages 251-269
    3. Sougat Misra, Mikael Björnstedt
      Pages 271-286
    4. Oliver Micke, Jens Buentzel, Ralph Mücke
      Pages 287-300
  8. The Role of Selenium in Various Diseases and Health Issues

    1. Front Matter
      Pages 301-301
    2. Ji-Chang Zhou, Jun Zhou, Liqin Su, Kaixun Huang, Xin Gen Lei
      Pages 317-344
    3. Alain Lescure, Mireille Baltzinger, Ester Zito
      Pages 345-362
    4. Roland Gärtner
      Pages 363-371
    5. Franziska Ebert, Sandra M. Müller, Soeren Meyer, Tanja Schwerdtle
      Pages 373-391
    6. Ivana Vinković Vrček
      Pages 393-412
  9. Selenium Analytics, Speciation and Biomonitoring

    1. Front Matter
      Pages 449-449
    2. Kostja Renko
      Pages 451-465
    3. Thomas Göen, Annette Greiner
      Pages 467-494
    4. Yasumitsu Ogra, Yasumi Anan, Noriyuki Suzuki
      Pages 495-511
  10. Back Matter
    Pages 513-522

About this book


This book summarizes the fast-growing and current knowledge about selenium interaction with cancer, diabetes, neuro-degeneration, heart disease, muscle disorders, HIV and several more. A special focus will be placed on in-depth knowledge about gene expression, selenoprotein biosynthesis, seleno-metabolism--as well as the molecular pathways, physiological roles, and the molecular action of selenium including interaction with other elements and vitamins or as Se-nanoparticles. The reader will receive the newest information regarding redox status and redox regulatory systems, specifically in relation to different glutathione peroxidases and thioredoxin-reductases as well as about cellular bioavailability and cytotoxicity, de-balanced immune response, inflammation or dietary aspects.


selenium selenium and disease selenoproteins seleno-metabolism redox systems inflammatory mediators selenium toxicity

Editors and affiliations

  • Bernhard Michalke
    • 1
  1. 1.Research Unit: Analytical BioGeoChemistryHelmholtz Zentrum München – German Research Center for Environmental Health GmbHNeuherbergGermany

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-95389-2
  • Online ISBN 978-3-319-95390-8
  • Series Print ISSN 2168-4219
  • Series Online ISSN 2168-4235
  • Buy this book on publisher's site