Diffuse Gastric Cancer

  • Tiago Biachi de Castria
  • Rodrigo Santa Cruz Guindalini

Table of contents

  1. Front Matter
    Pages i-x
  2. Tiago Biachi de Castria, José Mauricio Mota
    Pages 1-3
  3. Williams Fernandes Barra, Samia Demachki, Geraldo Ishak, Paulo Pimentel de Assumpção
    Pages 5-14
  4. Bruno Frederico Medrado, Bruno da Costa Martins
    Pages 15-25
  5. Maria Aparecida Azevedo Koike Folgueira, Marina Candido Visontai Cormedi, Daniela Marques Saccaro, Maria Lucia Hirata Katayama
    Pages 27-40
  6. Ana Carolina Ribeiro Chaves de Gouvea, Andrea Clemente Baptista Silva, Carolina Ribeiro Victor, Elizabeth Zambrano Mendoza, Mirella Nardo, Rodrigo Santa Cruz Guindalini
    Pages 41-48
  7. Ulysses Ribeiro Jr., Fernando Simionato Perrotta
    Pages 49-56
  8. Andre Tsin Chih Chen, Carlos Bo Chur Hong
    Pages 57-64
  9. Guilherme Luiz Stelko Pereira, Eduardo Saadi Neto
    Pages 65-75
  10. Back Matter
    Pages 77-81

About this book


We live in an era of personalized medicine and the knowledge about pathophysiology of diffuse gastric cancer has had many advances. Thus, the role of this work is to clarify what is new from diagnosis to treatment of this disease in order to treat patients in the most tailored manner as possible.

Almost all phase III trials in gastric cancer have been performed without taking in consideration histologic subtypes, i.e. they have disregarded the differences between diffuse gastric cancer and general gastric cancer. However, the clinical practice reveals that diffuse gastric cancer is a completely distinct disease, with an aggressive course and generally worse prognosis. The loss of cohesion between tumor cells due to the loss of E-cadherin synthesis is the critical point on the oncogenesis of diffuse gastric cancer and is at the root of its marked heredity. This book intends to give special attention to Diffuse Gastric Cancer as a particular oncological entity, differentiating it from general gastric cancer, exploring and discussing all its peculiarities, and addressing the basic aspects (pathology and genetics) along with the most recent therapeutic alternatives for this condition.


Gastric cancer Diffuse cancer Hereditary cancer Familial cancer Chemotherapy

Editors and affiliations

  • Tiago Biachi de Castria
    • 1
  • Rodrigo Santa Cruz Guindalini
    • 2
  1. 1.Instituto do Câncer do Estado de São PauloSão PauloBrazil
  2. 2.CLIONSalvadorBrazil

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-95233-8
  • Online ISBN 978-3-319-95234-5
  • Buy this book on publisher's site