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Table of contents

  1. Front Matter
    Pages i-xviii
  2. Why Consider Mechanisms?

    1. Front Matter
      Pages 1-1
    2. Veli-Pekka Parkkinen, Christian Wallmann, Michael Wilde, Brendan Clarke, Phyllis Illari, Michael P. Kelly et al.
      Pages 3-9 Open Access
    3. Veli-Pekka Parkkinen, Christian Wallmann, Michael Wilde, Brendan Clarke, Phyllis Illari, Michael P. Kelly et al.
      Pages 11-21 Open Access
    4. Veli-Pekka Parkkinen, Christian Wallmann, Michael Wilde, Brendan Clarke, Phyllis Illari, Michael P. Kelly et al.
      Pages 23-33 Open Access
  3. Tools for Working with Mechanisms

    1. Front Matter
      Pages 35-35
    2. Veli-Pekka Parkkinen, Christian Wallmann, Michael Wilde, Brendan Clarke, Phyllis Illari, Michael P. Kelly et al.
      Pages 37-59 Open Access
  4. Core Principles

    1. Front Matter
      Pages 61-61
    2. Veli-Pekka Parkkinen, Christian Wallmann, Michael Wilde, Brendan Clarke, Phyllis Illari, Michael P. Kelly et al.
      Pages 63-75 Open Access
    3. Veli-Pekka Parkkinen, Christian Wallmann, Michael Wilde, Brendan Clarke, Phyllis Illari, Michael P. Kelly et al.
      Pages 77-90 Open Access
    4. Veli-Pekka Parkkinen, Christian Wallmann, Michael Wilde, Brendan Clarke, Phyllis Illari, Michael P. Kelly et al.
      Pages 91-98 Open Access
  5. Particular Applications

    1. Front Matter
      Pages 99-99
    2. Veli-Pekka Parkkinen, Christian Wallmann, Michael Wilde, Brendan Clarke, Phyllis Illari, Michael P. Kelly et al.
      Pages 101-110 Open Access
    3. Veli-Pekka Parkkinen, Christian Wallmann, Michael Wilde, Brendan Clarke, Phyllis Illari, Michael P. Kelly et al.
      Pages 111-120 Open Access
    4. Veli-Pekka Parkkinen, Christian Wallmann, Michael Wilde, Brendan Clarke, Phyllis Illari, Michael P. Kelly et al.
      Pages 121-125 Open Access

About this book

Introduction

This book is open access under a CC BY license. 

This book is the first to develop explicit methods for evaluating evidence of mechanisms in the field of medicine. It explains why it can be important to make this evidence explicit, and describes how to take such evidence into account in the evidence appraisal process. In addition, it develops procedures for seeking evidence of mechanisms, for evaluating evidence of mechanisms, and for combining this evaluation with evidence of association in order to yield an overall assessment of effectiveness. 

Evidence-based medicine seeks to achieve improved health outcomes by making evidence explicit and by developing explicit methods for evaluating it. To date, evidence-based medicine has largely focused on evidence of association produced by clinical studies. As such, it has tended to overlook evidence of pathophysiological mechanisms and evidence of the mechanisms of action of interventions. 

The book offers a useful guide for all those whose work involves evaluating evidence in the health sciences, including those who need to determine the effectiveness of health interventions and those who need to ascertain the effects of environmental exposures.

Keywords

Evidence-based medicine Mechanisms in medicine Evaluating evidence Medical methodology Evidence hierarchy Philosophy of medicine Mechanisms in literature Mechanism hypothesis Hypothesize a mechanism evidence of mechanisms Assessing exposures evidence and status of claim. Humanities Research Evidence-Based Medicine (EBM) Molecular epidemiology ebmplus.org analogous epistemic theory external validity effects of environmental exposures Open access

Authors and affiliations

  • Veli-Pekka Parkkinen
    • 1
  • Christian Wallmann
    • 2
  • Michael Wilde
    • 3
  • Brendan Clarke
    • 4
  • Phyllis Illari
    • 5
  • Michael P Kelly
    • 6
  • Charles Norell
    • 7
  • Federica Russo
    • 8
  • Beth Shaw
    • 9
  • Jon Williamson
    • 10
  1. 1.Department of PhilosophyUniversity of BergenBergenNorway
  2. 2.Centre for ReasoningUniversity of KentCanterburyUnited Kingdom
  3. 3.Centre for ReasoningUniversity of KentCanterburyUnited Kingdom
  4. 4.Department of Science and Technology StudiesUniversity College LondonLondonUnited Kingdom
  5. 5.Department of Science and Technology StudiesUniversity College LondonLondonUnited Kingdom
  6. 6.Public Health and Primary CareUniversity of CambridgeCambridgeUnited Kingdom
  7. 7.Cancer Research UKLondonUnited Kingdom
  8. 8.Department of PhilosophyUniversity of AmsterdamAmsterdamThe Netherlands
  9. 9.Centre for Evidence-Based PolicyOregon Health & Science UniversityPortlandUSA
  10. 10.Centre for ReasoningUniversity of KentCanterburyUnited Kingdom

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-94610-8
  • Copyright Information The Editor(s) (if applicable) and The Author(s) 2018
  • License CC BY
  • Publisher Name Springer, Cham
  • eBook Packages Religion and Philosophy
  • Print ISBN 978-3-319-94609-2
  • Online ISBN 978-3-319-94610-8
  • Series Print ISSN 2211-4548
  • Series Online ISSN 2211-4556
  • Buy this book on publisher's site