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Stem Cell Genetics for Biomedical Research

Past, Present, and Future

  • Raul Delgado-Morales

Table of contents

  1. Front Matter
    Pages i-xi
  2. Stem Cells for Brain Disorders

    1. Front Matter
      Pages 1-1
    2. Juliana Minardi Nascimento, Veronica M. Saia-Cereda, Giuliana S. Zuccoli, Danielle Gouvêa-Junqueira, Daniel Martins-de-Souza
      Pages 13-26
    3. Keita Tsujimura, Kinichi Nakashima
      Pages 27-41
    4. James Hong, Christopher E. Rodgers, Michael G. Fehlings
      Pages 43-72
    5. Giulio Volpe, Joshua D. Bernstock, Luca Peruzzotti-Jametti, Stefano Pluchino
      Pages 87-132
  3. Stem Cells for Cardiovascular Diseases

  4. Stem Cells for General Medicine

    1. Front Matter
      Pages 195-195
    2. Rosa Gasa, Meritxell Rovira
      Pages 197-220
    3. E. Martínez-Sarrà, S. Montori, C. Gil-Recio, R. Núñez-Toldrà, N. Carrio Bertran, A. Al Madhoun et al.
      Pages 221-240
    4. R. A. Contreras, N. Luque, F. Djouad, Roberto Elizondo-Vega, Patricia Luz-Crawford
      Pages 241-269
    5. Meredith Davis, Katja Gassner, Ruth Rodriguez-Barrueco, David Llobet-Navas
      Pages 271-309
  5. Technical Challenges and Future

    1. Front Matter
      Pages 335-335
    2. Begoña Aran, Ángel Raya, Anna Veiga
      Pages 337-367
  6. Back Matter
    Pages 413-426

About this book

Introduction

This book looks at where stem cell technology is presently and how it is instrumental in advancing the field of disease modeling and cell transplantation. By focusing on major human disorders such as Alzheimer’s disease, cancer, and heart disorders, the book summarizes the major findings in the field of human stem cells and dissect the current limitations on our understanding of stem cells biology. The chapters focus on the genetics, genomics, epigenetics and physiology of stem cells models, together with technological advances on molecular biology such as CRISPR/Cas9 or epigenetic editing, that will be instrumental in the future of human disease modeling and treatment. 

In base of the limitations of current disease models and in front of the unmet necessity of finding therapeutical interventions for human disorders, the availability of stem cell technology has opened new doors for several fields. The unlimited self-renewal capacity and more extensive differentiation potential of stem cells offers a theoretically inexhaustible and replenishable source of any cell subtype. Since Professor Shinya Yamanaka described it, 10 years ago in his seminal paper, that somatic cells could be reprogrammed to inducible stem cells (iPSC) just by expressing four transcription factors, the field of has exploded, especially its applications in biomedical research.

Keywords

disease modeling cell transplantation somatic brain disorders cardiovascular therapeutics

Editors and affiliations

  • Raul Delgado-Morales
    • 1
  1. 1.Duran i Reynals HospitalBellvitge Biomedical Research Institute (IDIBELL)BarcelonaSpain

Bibliographic information