A Clinical Guide

  • Nicole L.┬áDraper

Table of contents

  1. Front Matter
    Pages i-xi
  2. Causes of Chimerism in Humans

    1. Front Matter
      Pages 1-1
    2. Nicole L. Draper, Kristy Crooks
      Pages 3-17
    3. Linda Marie Randolph, Ramen H. Chmait
      Pages 19-31
    4. Joel N. Kniep
      Pages 33-48
  3. Clinical Identification and Consequences of Chimerism

    1. Front Matter
      Pages 49-49
    2. Kayla Sheets, Robert Wenk
      Pages 51-63
    3. Ignatia B. Van den Veyver
      Pages 65-79
    4. Opal L. Reddy, Dawn C. Ward, Andrea M. McGonigle
      Pages 81-103
    5. Alexa J. Siddon, Christopher A. Tormey
      Pages 105-117
    6. Nicole L. Draper, Jamie E. Kallan
      Pages 119-134
    7. Andrea R. Merchak, Anita Y. Chhabra, Joseph R. Leventhal, Suzanne T. Ildstad
      Pages 135-152
    8. Nathalie Lambert
      Pages 153-179
    9. Valentina Cirello, Laura Fugazzola
      Pages 181-194
  4. Back Matter
    Pages 195-200

About this book


This text provides a comprehensive, up-to-date review of chimerism. The first part of the volume presents the causes of chimerism, specifically focusing on fertilization and early embryonic errors, pregnancy and multiple gestations, and transplantation and transfusion. The second part of the volume outlines clinical identification and consequences of chimerism. Chapters in this section focus on the effects of chimerism on testing in relationship determination and forensics, prenatal genetic testing and screening, and blood and HLA typing. This part also reviews new data concerning matching donors and recipients for transplantation, while outlining the risks of transplantation, such as graft-vs-host disease and passenger lymphocyte syndrome.  Additionally, evidence on the role of chimerism in autoimmune disease and cancer is presented.  

Written by experts in the field, Chimerism: A Clinical Guide is a valuable resource for clinicians and researchers that will help guide patient management and stimulate investigative efforts.


tetragametic chimerism dispermic chimerism fetomaternal microchimerism solid organ transplant hematopoietic stem cell transplant transfusion microchimerism

Editors and affiliations

  • Nicole L.┬áDraper
    • 1
  1. 1.Department of PathologyUniversity of Colorado School of MedicineAuroraUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-89865-0
  • Online ISBN 978-3-319-89866-7
  • Buy this book on publisher's site