Diagnostic Meta-Analysis

A Useful Tool for Clinical Decision-Making

  • Giuseppe Biondi-Zoccai

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Part I

    1. Front Matter
      Pages 1-1
    2. Giuseppe Biondi-Zoccai, Mariangela Peruzzi, Simona Mastrangeli, Giacomo Frati
      Pages 3-9
    3. Mical Paul
      Pages 11-17
    4. Giuseppe Biondi-Zoccai, Simona Mastrangeli, Mariangela Peruzzi, Giacomo Frati
      Pages 19-30
    5. Michail Tsagris, Konstantinos C. Fragkos
      Pages 31-40
  3. Part II

    1. Front Matter
      Pages 41-41
    2. José Mauro Madi, Machline Paim Paganella, Isnard Elman Litvin, Eliana Marcia Wendland
      Pages 43-58
    3. Alison Booth, Julie Jones-Diette
      Pages 59-75
    4. Su Golder, Julie Glanville
      Pages 77-91
    5. Luca Testa, Mario Bollati
      Pages 93-98
    6. Valentina Pecoraro
      Pages 99-114
    7. Paul-Christian Bürkner
      Pages 115-124
    8. Antonia Zapf
      Pages 125-160
    9. Philipp Doebler, Paul-Christian Bürkner, Gerta Rücker
      Pages 161-181
    10. Umberto Benedetto, Colin Ng
      Pages 199-203
    11. Ersilia Lucenteforte, Alessandra Bettiol, Salvatore De Masi, Gianni Virgili
      Pages 205-227
  4. Part III

    1. Front Matter
      Pages 229-229
    2. Bashar J. Qumseya, Michael Wallace
      Pages 249-261
    3. Sulbaran Marianny, Sousa Afonso, Bustamante-Lopez Leonardo
      Pages 263-284
    4. Eliana Al Haddad, Hutan Ashrafian, Thanos Athanasiou
      Pages 285-302
  5. Part IV

    1. Front Matter
      Pages 303-303
    2. Yulun Liu, Yong Chen
      Pages 305-315
    3. Giuseppe Biondi-Zoccai
      Pages 317-319

About this book


This book is the first exclusively devoted to the systematic synthesis of diagnostic test accuracy studies. It builds upon the major recent developments in reporting standards, search methods, and, in particular, statistical tools specifically devoted to diagnostic studies. In addition, it borrows extensively from the latest advances in systematic reviews and meta-analyses of intervention studies. After a section dedicated to methods for designing reviews, synthesizing evidence and appraising inconsistency in research, the application of these approaches is demonstrated in the context of case studies from various clinical disciplines.

Diagnosis is central in medical decision-making, and in many other fields of human endeavor, such as education and psychology. The plurality of sources of evidence on diagnostic test accuracy poses a huge challenge for practitioners and researchers, as do the multiple dimensions of evidence validity, which include sensitivity, specificity, predictive values, and likelihood ratios.

This book offers an invaluable resource for anyone aiming to improve decision-making processes in diagnosis, classification or risk prognostication, from epidemiologists to biostatisticians, radiologists, laboratory physicians and graduate students, as any physician interested in refining his methodological skills in clinical diagnosis.


Comparative effectiveness research Evidence-based medicine Outcome research Systematic review Diagnostic odds ratio Sensitivity Specificity Likelihood ratio Predictive value

Editors and affiliations

  • Giuseppe Biondi-Zoccai
    • 1
  1. 1.Department of Medico-Surgical SciencesSapienza University of RomeLatinaItaly

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-78965-1
  • Online ISBN 978-3-319-78966-8
  • Buy this book on publisher's site