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Carbohydrate-Based Interactions at the Molecular and the Cellular Level

  • Kieran L. Hudson

Part of the Springer Theses book series (Springer Theses)

Table of contents

  1. Front Matter
    Pages i-xxix
  2. Kieran L. Hudson
    Pages 1-34
  3. Analysing Protein–Carbohydrate Interactions at the Molecular Level

    1. Front Matter
      Pages 35-35
  4. Carbohydrate-Modified Materials for Tissue Engineering

    1. Front Matter
      Pages 87-87
    2. Kieran L. Hudson
      Pages 89-101
  5. Conclusions and Supplementary Information

    1. Front Matter
      Pages 129-129
    2. Kieran L. Hudson
      Pages 131-135
    3. Kieran L. Hudson
      Pages 137-198

About this book

Introduction

This book offers a clearly written and highly accessible account of two different aspects of carbohydrate chemistry. Carbohydrates are an essential component of life and have many important biological functions, but the details of how carbohydrates interact with other biomolecules to mediate biological signalling remain unclear. Firstly, this thesis details innovative methods to mine protein structural data to uncover new features of carbohydrate-based interactions. It also explains these findings using physical chemistry, specifically CH–pi interactions associated with the properties of the interacting partners. 

Carbohydrates are also critical for tissue growth and development, yet are underexploited in the materials science that underpins much of regenerative medicine. As such, the second part of this thesis describes a diverse array of techniques ranging from synthetic chemistry and enzymatic synthesis to prepare a wide variety of carbohydrates, and materials chemistry to prepare glycosylated hydrogels, to cell biology to determine the effects on cellular development for tissue engineering applications.

Keywords

Protein-carbohydrate Interactions Aromatic Interactions Ligand Binding Peptide-based Materials Smart Biomaterials Functionalised Materials CH-pi Interactions Cellular Development Carbohydrate Chemistry

Authors and affiliations

  • Kieran L. Hudson
    • 1
  1. 1.Department of ChemistryUniversity of British ColumbiaVancouverCanada

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-77706-1
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-3-319-77705-4
  • Online ISBN 978-3-319-77706-1
  • Series Print ISSN 2190-5053
  • Series Online ISSN 2190-5061
  • Buy this book on publisher's site