© 2018

Hereditary Colorectal Cancer

Genetic Basis and Clinical Implications

  • Laura Valle
  • Stephen B. Gruber
  • Gabriel Capellá
  • Comprehensive and updated coverage of the topic

  • Novel findings and challenges discussed

  • Provides coverage of issues ranging from genetics to clinical description of the syndromes


Table of contents

  1. Genetic Diagnostics and Clinical Management

    1. Heather Hampel, Rachel Pearlman, Deborah Cragun
      Pages 233-255
    2. Maurizio Genuardi, Elke Holinski-Feder, Andreas Laner, Alexandra Martins
      Pages 257-280
    3. Fay Kastrinos, Gregory Idos, Giovanni Parmigiani
      Pages 281-303
    4. Neda Stjepanovic, Leticia Moreira, Judith Balmaña, Joan Brunet
      Pages 305-326
    5. Johannes Dörner, Mahmoud Taghavi Fallahpour, Gabriela Möslein
      Pages 327-347
    6. Reagan M. Barnett, Ester Borras, N. Jewel Samadder, Eduardo Vilar
      Pages 349-365
    7. Matthias Kloor, Magnus von Knebel Doeberitz
      Pages 367-384
    8. David J. Hermel, Stephen B. Gruber
      Pages 385-399
    9. Eduardo Vilar, Ramón Salazar, Josep Tabernero
      Pages 401-413
  2. Registries and Databases

    1. Front Matter
      Pages 415-415
    2. Pål Møller, Sigve Nakken, Eivind Hovig
      Pages 417-426
    3. Mark A. Jenkins, Aung K. Win, Noralane M. Lindor
      Pages 427-459
    4. Pål Møller, Sigve Nakken, Eivind Hovig
      Pages 461-468
    5. John Paul Plazzer, Johan den Dunnen, Finlay Macrae
      Pages 469-478
    6. Mark A. Jenkins, Jeanette C. Reece, Aung K. Win
      Pages 479-495
  3. Back Matter
    Pages 497-505

About this book


This book provides information on a wide variety of  issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention. Moreover, current hot issues, such as the identification of novel causal genes and the challenges we face, and the relevance of cancer risk modifiers, both genetic and environmental, are also discussed.  

This reference book is great for geneticists, oncologists, genetic counselors, researchers, clinicians, surgeons and nurses dedicated to, or interested in,  hereditary cancer.  The best and most recognized experts in the field have contributed to this project, guaranteeing updated information, accuracy and the discussion of topical issues.


epigenetics genetic variants polyposis mutation gene Modifiers

Editors and affiliations

  • Laura Valle
    • 1
  • Stephen B. Gruber
    • 2
  • Gabriel Capellá
    • 3
  1. 1.Hereditary Cancer ProgramCatalan Institute of Oncology, IDIBELL and CIBERONC, Hospitalet de LlobregatBarcelonaSpain
  2. 2.University of Southern CaliforniaNorris Comprehensive Cancer CenterLos AngelesUSA
  3. 3.Hereditary Cancer ProgramCatalan Institute of Oncology, IDIBELL and CIBERONC, Hospitalet de LlobregatBarcelonaSpain

About the editors

Laura Valle, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute, Av. Gran Via 199-203, 08908
Barcelona, Spain
Prof. Dr. Stephen Gruber, Keck School of Medicine, University of Southern California, 1975 Zonal Ave, Los Angeles, 90033, USA
Dr. Gabriel Capella, Institut Català d'Oncologia (ICO), Av. de la Granvia de l'Hospitalet 199, 08907 Barcelona, Spain

Bibliographic information

  • Book Title Hereditary Colorectal Cancer
  • Book Subtitle Genetic Basis and Clinical Implications
  • Editors Laura Valle
    Stephen B. Gruber
    Gabriel Capellá
  • DOI
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-74258-8
  • Softcover ISBN 978-3-030-08948-1
  • eBook ISBN 978-3-319-74259-5
  • Edition Number 1
  • Number of Pages X, 505
  • Number of Illustrations 14 b/w illustrations, 39 illustrations in colour
  • Topics Gene Function
    Cancer Research
  • Buy this book on publisher's site


“This unique book is designed as a consultative source for individuals involved in the care of patients with colorectal cancer and patients at risk due to familial genetic testing. … Genetics counselors, medical geneticists, surgeons, and oncology specialists would find this book extremely useful. … One of the most impressive features of this book is the very useful abstract at the beginning of every chapter. … At the end, there is a section of registries and databases, extremely useful tools.” (Luis F. Escobar, Doody's Book Reviews, October, 2018)​