© 2018

Hereditary Colorectal Cancer

Genetic Basis and Clinical Implications

  • Laura Valle
  • Stephen B. Gruber
  • Gabriel Capellá
  • Comprehensive and updated coverage of the topic

  • Novel findings and challenges discussed

  • Provides coverage of issues ranging from genetics to clinical description of the syndromes


Table of contents

  1. Front Matter
    Pages i-x
  2. Genetic Causes and Associated Phenotypes: Hereditary Nonpolyposis CRC

    1. Front Matter
      Pages 1-1
    2. Elena M. Stoffel, Matthew B. Yurgelun, C. Richard Boland
      Pages 3-19
    3. Gardenia Vargas-Parra, Matilde Navarro, Marta Pineda, Gabriel Capellá
      Pages 21-41
    4. Chrystelle Colas, Laurence Brugières, Katharina Wimmer
      Pages 43-54
  3. Genetic Causes and Associated Phenotypes: Gastrointestinal Polyposis Syndromes

    1. Front Matter
      Pages 91-91
    2. Maartje Nielsen, Stephan Aretz
      Pages 99-111
    3. Claire Palles, Andrew Latchford, Laura Valle
      Pages 113-134
    4. Maartje Nielsen, Stephan Aretz
      Pages 135-148
    5. Joanne Ngeow, Eliza Courtney, Kiat Hon Lim, Charis Eng
      Pages 165-183
    6. Huw Thomas, Ian Tomlinson
      Pages 185-192
    7. Sabela Carballal, Francesc Balaguer, Antoni Castells
      Pages 193-205
  4. Genetic Diagnostics and Clinical Management

    1. Front Matter
      Pages 207-207
    2. Conxi Lázaro, Lidia Feliubadaló, Jesús del Valle
      Pages 209-232

About this book


This book provides information on a wide variety of  issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention. Moreover, current hot issues, such as the identification of novel causal genes and the challenges we face, and the relevance of cancer risk modifiers, both genetic and environmental, are also discussed.  

This reference book is great for geneticists, oncologists, genetic counselors, researchers, clinicians, surgeons and nurses dedicated to, or interested in,  hereditary cancer.  The best and most recognized experts in the field have contributed to this project, guaranteeing updated information, accuracy and the discussion of topical issues.


epigenetics genetic variants polyposis mutation gene Modifiers

Editors and affiliations

  • Laura Valle
    • 1
  • Stephen B. Gruber
    • 2
  • Gabriel Capellá
    • 3
  1. 1.Hereditary Cancer ProgramCatalan Institute of Oncology, IDIBELL and CIBERONC, Hospitalet de LlobregatBarcelonaSpain
  2. 2.University of Southern CaliforniaNorris Comprehensive Cancer CenterLos AngelesUSA
  3. 3.Hereditary Cancer ProgramCatalan Institute of Oncology, IDIBELL and CIBERONC, Hospitalet de LlobregatBarcelonaSpain

About the editors

Laura Valle, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute, Av. Gran Via 199-203, 08908
Barcelona, Spain
Prof. Dr. Stephen Gruber, Keck School of Medicine, University of Southern California, 1975 Zonal Ave, Los Angeles, 90033, USA
Dr. Gabriel Capella, Institut Català d'Oncologia (ICO), Av. de la Granvia de l'Hospitalet 199, 08907 Barcelona, Spain

Bibliographic information

  • Book Title Hereditary Colorectal Cancer
  • Book Subtitle Genetic Basis and Clinical Implications
  • Editors Laura Valle
    Stephen B. Gruber
    Gabriel Capellá
  • DOI
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-74258-8
  • Softcover ISBN 978-3-030-08948-1
  • eBook ISBN 978-3-319-74259-5
  • Edition Number 1
  • Number of Pages X, 505
  • Number of Illustrations 14 b/w illustrations, 39 illustrations in colour
  • Topics Gene Function
    Cancer Research
  • Buy this book on publisher's site


“This unique book is designed as a consultative source for individuals involved in the care of patients with colorectal cancer and patients at risk due to familial genetic testing. … Genetics counselors, medical geneticists, surgeons, and oncology specialists would find this book extremely useful. … One of the most impressive features of this book is the very useful abstract at the beginning of every chapter. … At the end, there is a section of registries and databases, extremely useful tools.” (Luis F. Escobar, Doody's Book Reviews, October, 2018)​