Hereditary Colorectal Cancer

Genetic Basis and Clinical Implications

  • Laura Valle
  • Stephen B. Gruber
  • Gabriel Capellá

Table of contents

  1. Front Matter
    Pages i-x
  2. Genetic Causes and Associated Phenotypes: Hereditary Nonpolyposis CRC

    1. Front Matter
      Pages 1-1
    2. Elena M. Stoffel, Matthew B. Yurgelun, C. Richard Boland
      Pages 3-19
    3. Gardenia Vargas-Parra, Matilde Navarro, Marta Pineda, Gabriel Capellá
      Pages 21-41
    4. Chrystelle Colas, Laurence Brugières, Katharina Wimmer
      Pages 43-54
  3. Genetic Causes and Associated Phenotypes: Gastrointestinal Polyposis Syndromes

    1. Front Matter
      Pages 91-91
    2. Maartje Nielsen, Stephan Aretz
      Pages 99-111
    3. Claire Palles, Andrew Latchford, Laura Valle
      Pages 113-134
    4. Maartje Nielsen, Stephan Aretz
      Pages 135-148
    5. Joanne Ngeow, Eliza Courtney, Kiat Hon Lim, Charis Eng
      Pages 165-183
    6. Huw Thomas, Ian Tomlinson
      Pages 185-192
    7. Sabela Carballal, Francesc Balaguer, Antoni Castells
      Pages 193-205
  4. Genetic Diagnostics and Clinical Management

    1. Front Matter
      Pages 207-207
    2. Conxi Lázaro, Lidia Feliubadaló, Jesús del Valle
      Pages 209-232
    3. Heather Hampel, Rachel Pearlman, Deborah Cragun
      Pages 233-255
    4. Maurizio Genuardi, Elke Holinski-Feder, Andreas Laner, Alexandra Martins
      Pages 257-280
    5. Fay Kastrinos, Gregory Idos, Giovanni Parmigiani
      Pages 281-303
    6. Neda Stjepanovic, Leticia Moreira, Judith Balmaña, Joan Brunet
      Pages 305-326
    7. Johannes Dörner, Mahmoud Taghavi Fallahpour, Gabriela Möslein
      Pages 327-347
    8. Reagan M. Barnett, Ester Borras, N. Jewel Samadder, Eduardo Vilar
      Pages 349-365
    9. Matthias Kloor, Magnus von Knebel Doeberitz
      Pages 367-384
    10. David J. Hermel, Stephen B. Gruber
      Pages 385-399
    11. Eduardo Vilar, Ramón Salazar, Josep Tabernero
      Pages 401-413
  5. Registries and Databases

    1. Front Matter
      Pages 415-415
    2. Pål Møller, Sigve Nakken, Eivind Hovig
      Pages 417-426
    3. Mark A. Jenkins, Aung K. Win, Noralane M. Lindor
      Pages 427-459
    4. Pål Møller, Sigve Nakken, Eivind Hovig
      Pages 461-468
    5. John Paul Plazzer, Johan den Dunnen, Finlay Macrae
      Pages 469-478
    6. Mark A. Jenkins, Jeanette C. Reece, Aung K. Win
      Pages 479-495
  6. Back Matter
    Pages 497-505

About this book


This book provides information on a wide variety of  issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention. Moreover, current hot issues, such as the identification of novel causal genes and the challenges we face, and the relevance of cancer risk modifiers, both genetic and environmental, are also discussed.  

This reference book is great for geneticists, oncologists, genetic counselors, researchers, clinicians, surgeons and nurses dedicated to, or interested in,  hereditary cancer.  The best and most recognized experts in the field have contributed to this project, guaranteeing updated information, accuracy and the discussion of topical issues.


epigenetics genetic variants polyposis mutation gene Modifiers

Editors and affiliations

  • Laura Valle
    • 1
  • Stephen B. Gruber
    • 2
  • Gabriel Capellá
    • 3
  1. 1.Hereditary Cancer ProgramCatalan Institute of Oncology, IDIBELL and CIBERONC, Hospitalet de LlobregatBarcelonaSpain
  2. 2.University of Southern CaliforniaNorris Comprehensive Cancer CenterLos AngelesUSA
  3. 3.Hereditary Cancer ProgramCatalan Institute of Oncology, IDIBELL and CIBERONC, Hospitalet de LlobregatBarcelonaSpain

Bibliographic information