Recurrent Implantation Failure

Etiologies and Clinical Management

  • Jason M. Franasiak
  • Richard T. Scott Jr.

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Chelsea Fox, Bruce A. Lessey
    Pages 1-19
  3. Jason M. Franasiak, Richard T. Scott
    Pages 21-31
  4. Sorena Keihani, Jeremy B. Myers, James M. Hotaling
    Pages 33-58
  5. Daniel J. Kaser, Catherine Racowsky
    Pages 59-75
  6. Eric J. Forman, Nathan Treff, Rebekah S. Zimmerman
    Pages 77-91
  7. Diana Alecsandru, Juan A. Garcia-Velasco
    Pages 93-102
  8. Jeffrey L. Deaton, Bonnie Patel, Erika Johnston-MacAnanny, Jie Yu, Shannon D. Whirledge, Alexandra Wilson et al.
    Pages 103-124
  9. Shelby A. Neal, Jason M. Franasiak, Richard T. Scott
    Pages 125-134
  10. Scott Morin, Baris Ata, Emre Seli
    Pages 135-152
  11. Jeffrey M. Goldberg, Julian Gingold, Natalia Llarena
    Pages 153-174
  12. Jason M. Franasiak, Inmaculada Moreno, Carlos Simon
    Pages 175-195
  13. Andrea Mechanick Braverman, Keren Sofer
    Pages 197-210
  14. Back Matter
    Pages 211-215

About this book


This unique text discusses the wide range of causes and pathophysiologic conditions contributing to recurrent implantation failure (RIF) and the current treatment approaches to best approach this challenging patient population. Beginning with a presentation of the mechanism of normal implantation, the physiologic synchrony between embryo and endometrium, and the roles of both gametes and embryos in RIF, the book then examines the various genetic, immune and environmental factors involved. Abnormalities of the hematologic and endocrine system, as well as those of the anatomy and microbiome, are described in detail. Last but no less important, the psychological stress and treatment of patients experiencing RIF is discussed. 

Assisted reproductive technology (ART) success has increased substantially over the past three decades. However, despite these advances, recurrent implantation failure is still a common issue confronting patients and clinicians, and RIF represents one of the greatest challenges in ART and remains a source of frustration and disappointment for patients, clinicians, and researchers involved in the process. Providing an in-depth investigation into the pathophysiology and biological mechanisms of RIF and its clinical management, this will be an excellent resource for reproductive endocrinologists and infertility specialists. 


Anatomic abnormality ART Assisted hatching Assisted reproductive technology Blastocyst transfer Embryo Endometrial synchrony Environmental factor Gamete Immune factors Microbiome Oocyte Pregnancy loss Preimplantation genetic diagnosis Recurrent implant failure RIF Sperm

Editors and affiliations

  • Jason M. Franasiak
    • 1
  • Richard T. Scott Jr.
    • 2
  1. 1.Reproductive Medicine Associates of NJThomas Jefferson UniversityBasking RidgeUSA
  2. 2.Reproductive Medicine Associates of NJThomas Jefferson UniversityBasking RidgeUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-71966-5
  • Online ISBN 978-3-319-71967-2
  • Buy this book on publisher's site