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Nuclear Pore Complexes in Genome Organization, Function and Maintenance

  • Maximiliano D’Angelo

Table of contents

  1. Front Matter
    Pages i-viii
  2. Michael I. Robson, Andrea Rizzotto, Eric C. Schirmer
    Pages 1-34
  3. Carlo Randise-Hinchliff, Jason H. Brickner
    Pages 87-109
  4. Celia María Muñoz-Jiménez, Peter Askjaer
    Pages 137-158
  5. Marcela Raices, Maximiliano A. D’Angelo
    Pages 159-182
  6. Marie-Noelle Simon, Alkmini Kalousi, Evi Soutoglou, Vincent Géli, Catherine Dargemont
    Pages 201-218
  7. Masaharu Hazawa, Akiko Kobayashi, Richard W. Wong
    Pages 219-240

About this book

Introduction

The three-dimensional organization of the DNA inside the eukaryotic cell nucleus has emerged a critical regulator of genome integrity and function. Increasing evidence indicates that nuclear pore complexes (NPCs), the large protein channels that connect the nucleus to the cytoplasm, play a critical role in the establishment and maintenance of chromatin organization and in the regulation of gene activity. These findings, which oppose the traditional view of NPCs as channels with only one: the facilitation of nucleocytoplasmic molecule exchange, have completely transformed our understanding of these structures. This book describes our current knowledge of the role of NPCs in genome organization and gene expression regulation. It starts by providing an overview of the different compartments and structures of the nucleus and how they contribute to organizing the genome, then moves to examine the direct roles of NPCs and their components in gene expression regulation in different organisms, and ends by describing the function of nuclear pores in the infection and genome integration of HIV, in DNA repair and telomere maintenance, and in the regulation of chromosome segregation and mitosis. This book provides an intellectual backdrop for anyone interested in understanding how the gatekeepers of the nucleus contribute to safeguarding the integrity and function of the eukaryotic genome. 

Keywords

Genome Organisation Genomic Stability Nuclear Pore Complexes Nuclear Transport Nucleus

Editors and affiliations

  • Maximiliano D’Angelo
    • 1
  1. 1.Medical Discovery InstituteStandord Burham Prebys Medical Discovery InstituteLa JollaUSA

Bibliographic information