Heat Shock Proteins in the Immune System

  • Robert J. Binder
  • Pramod K. Srivastava

Table of contents

  1. Front Matter
    Pages i-x
  2. Structure of the HSPs in Relation to Chaperoning Peptides and Proteins

    1. Front Matter
      Pages 1-1
    2. Roman Kityk, Matthias P. Mayer
      Pages 3-20
    3. Michael A. Moses, Abbey D. Zuehlke, Len Neckers
      Pages 21-40
  3. Exposure of HSPs to Immune Cells

    1. Front Matter
      Pages 41-41
  4. Regulation of Immune Responses by Extracellular HSPs

  5. Back Matter
    Pages 181-185

About this book


Experts from around the world review the current field of the immunobiology of heat shock proteins, and provide a comprehensive account of how these molecules are spearheading efforts in the understanding of various pathways of the immune system. This one-stop resource contains numerous images to both help illustrate the research on heat shock proteins, and better clarify the field for the non-expert. Heat shock proteins (HSPs) were discovered in 1962 and were quickly recognized for their role in protecting cells from stress. Twenty years later, the immunogenicity of a select few HSPs was described, and for the past 30 years, these findings have been applied to numerous branches of immunology, including tumor immunology and immunosurveillance, immunotherapy, etiology of autoimmunity, immunotherapy of infectious diseases, and expression of innate receptors. While HSPs can be used to manipulate immune responses by exogenous administration, they appear to be involved in initiation of de novo immune responses to cancer and likely in the maintenance of immune homeostasis.  


biological pathways heat shock proteins immune system infectious diseases innate T cells HSP inhibitors Vascular Normalization

Editors and affiliations

  • Robert J. Binder
    • 1
  • Pramod K. Srivastava
    • 2
  1. 1.Department of ImmunologyUniversity of Pittsburgh, School of MedicinePittsburghUSA
  2. 2.Carole and Ray Neag Comprehensive Cancer Center and the Department of ImmunologyUniversity of Connecticut School of MedicineFarmingtonUSA

Bibliographic information