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Marburg- and Ebolaviruses

From Ecosystems to Molecules

  • Elke Mühlberger
  • Lisa L. Hensley
  • Jonathan S. Towner

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 411)

Table of contents

  1. Front Matter
    Pages i-x
  2. Maintenance in Nature and Spillover: Ecology, Outbreaks and Clinical Management

    1. Front Matter
      Pages 1-1
    2. Werner Slenczka
      Pages 3-21
    3. Brian R. Amman, Robert Swanepoel, Stuart T. Nichol, Jonathan S. Towner
      Pages 23-61
    4. Armand Sprecher, Michel Van Herp, Pierre E. Rollin
      Pages 93-113
    5. G. Marshall Lyon, Aneesh K. Mehta, Bruce S. Ribner
      Pages 115-137
  3. Disease: Pathogenesis and Protection

    1. Front Matter
      Pages 139-139
    2. César Muñoz-Fontela, Anita K. McElroy
      Pages 141-169
    3. Richard S. Bennett, Louis M. Huzella, Peter B. Jahrling, Laura Bollinger, Gene G. Olinger Jr, Lisa E. Hensley
      Pages 171-193
    4. Satoko Yamaoka, Logan Banadyga, Mike Bray, Hideki Ebihara
      Pages 195-227
    5. Elizabeth S. Higgs, Sheri A. Dubey, Beth A. G. Coller, Jakub K. Simon, Laura Bollinger, Robert A. Sorenson et al.
      Pages 229-261
    6. John Connor, Gary Kobinger, Gene Olinger
      Pages 263-290
  4. Replication: at Cellular Level and Below

    1. Front Matter
      Pages 291-291
    2. Judith Olejnik, Adam J. Hume, Daisy W. Leung, Gaya K. Amarasinghe, Christopher F. Basler, Elke Mühlberger
      Pages 293-322
    3. R.A. Davey, O. Shtanko, M. Anantpadma, Y. Sakurai, K. Chandran, W. Maury
      Pages 323-352
    4. Larissa Kolesnikova, Asuka Nanbo, Stephan Becker, Yoshihiro Kawaoka
      Pages 353-380
    5. Robert N. Kirchdoerfer, Hal Wasserman, Gaya K. Amarasinghe, Erica Ollmann Saphire
      Pages 381-417
  5. Tools and Taxonomy

    1. Front Matter
      Pages 419-419
    2. Thomas Hoenen, Janine Brandt, Yíngyún Caì, Jens H. Kuhn, Courtney Finch
      Pages 421-445

About this book

Introduction

This volume provides an overview of recent advances in our understanding of the biology of marburg- and ebolaviruses. It focuses on four essential areas: 1) ecology, outbreaks and clinical management, 2) disease, pathogenesis and protection, 3) virus replication inside the cell, and 4) molecular tools for virus study and taxonomy.

For 50 years, these viruses have spilled over sporadically and without warning from their wildlife reservoirs, often causing major outbreaks and high fatalities. The consequences can be devastating, with a clear potential for global reach, as demonstrated by the 2013 West African outbreak of Ebola virus, which led to over 28,000 reported cases across three continents and more than 11,000 deaths. Given the international threat posed by these viruses, the pace and scope of basic research have also greatly intensified, ranging from studies of virus emergence, epidemiology, antiviral countermeasures and human disease to detailed mechanistic studies of virus entry, replication, virion assembly and protein structure.

Written by internationally respected experts, this book will appeal to a wide audience and be a valuable resource for basic researchers, clinicians and advanced students alike.

Keywords

Antiviral responses Filoviraus replication Filovirus outbreak Filovirus vaccines Virus disease outbreak West Africa Ebola Clinical management

Editors and affiliations

  • Elke Mühlberger
    • 1
  • Lisa L. Hensley
    • 2
  • Jonathan S. Towner
    • 3
  1. 1.Boston University School of Medicine BostonUSA
  2. 2.NIAIDNational Institutes of Health NIAIDFrederickUSA
  3. 3.Centers for Disease Control & PreventionAtlantaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-68948-7
  • Copyright Information Springer International Publishing AG (outside the USA) 2017
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-68946-3
  • Online ISBN 978-3-319-68948-7
  • Series Print ISSN 0070-217X
  • Series Online ISSN 2196-9965
  • Buy this book on publisher's site