Antibody Therapy

Substitution – Immunomodulation – Monoclonal Immunotherapy

  • Paul Imbach

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Update of Substitutive and Immunomodulatory Antibodies/Drugs Indications

    1. Front Matter
      Pages 13-13
    2. Paul Imbach, Volker Wahn
      Pages 23-33
    3. Ramsha Khan, Alan H. Lazarus
      Pages 61-71
    4. Howard A. Liebman
      Pages 85-100
    5. Marinos C. Dalakas
      Pages 101-109
    6. Jochen H. O. Hoffmann, Alexander H. Enk
      Pages 111-118
  3. Basics of IgG Concentrates

    1. Front Matter
      Pages 119-119
    2. Volker Wahn, Peter Späth
      Pages 121-132
    3. Tchavdar L. Vassilev, Victor Kostov, Stephan von Gunten, Anastas D. Pashov
      Pages 133-150
    4. Peter J. Späth
      Pages 175-202
  4. Immune Thrombocytopenia: The First Immunomodulatory IgG Treatment

  5. Translation from Polyclonal to Monoclonal Antibody Treatment

About this book


This practical manual, written by well-known experts, reviews current indications for the use of IgG concentrates and some other modern immunomodulators and provides fundamental information on present-day immunomodulation in patients (and mice). The book opens by tracing the transition from IgG substitution to IgG immunomodulation and providing expert updates on immunomodulatory indications in autoimmune and inflammatory disorders, including hematologic, neurologic, dermatologic, and other diseases. Basic aspects of IgG concentrates, including methods of production, safety, currently available products, and mechanisms of action, are then discussed. An entire chapter is devoted to the different aspects of immunomodulatory IgG treatment in the bleeding disorder immune thrombocytopenia (ITP). Finally, the transition from polyclonal to monoclonal antibody (mAb) treatment is addressed in detail, covering mAb development, methods, mechanisms of action, adverse effects, and more. Particular attention is paid to the example of anti-CD20 (B-cell) antibody.


Immunoglobulin G Concentrate Immune Thrombocytopenia Immunomodulation Autoimmune Disorders Mangement of Immune Thrombocytopenia

Editors and affiliations

  • Paul Imbach
    • 1
  1. 1.Department of PediatricsMedical Faculty of the University of BaselBaselSwitzerland

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-68037-8
  • Online ISBN 978-3-319-68038-5
  • Buy this book on publisher's site