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Peptides and Peptide-based Biomaterials and their Biomedical Applications

  • Anwar Sunna
  • Andrew Care
  • Peter L. Bergquist

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1030)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Andrew Care, Peter L. Bergquist, Anwar Sunna
    Pages 21-36
  3. Rania S. Seoudi, Adam Mechler
    Pages 51-94
  4. Mitchell Boyd-Moss, Kate Fox, Milan Brandt, David Nisbet, Richard Williams
    Pages 95-129
  5. John Horsley, Jingxian Yu, Yuan Qi Yeoh, Andrew Abell
    Pages 131-153
  6. Nurcan Hastar, Elif Arslan, Mustafa O. Guler, Ayse B. Tekinay
    Pages 155-166
  7. Kavisha R. Ulapane, Brian M. Kopec, Mario E. G. Moral, Teruna J. Siahaan
    Pages 167-184
  8. Renata Kowalczyk, Paul W. R. Harris, Geoffrey M. Williams, Sung-Hyun Yang, Margaret A. Brimble
    Pages 185-227
  9. James T. Daniel, Richard J. Clark
    Pages 229-254
  10. Maxime Gestin, Moataz Dowaidar, Ülo Langel
    Pages 255-264
  11. Lucia Feni, Ines Neundorf
    Pages 279-295
  12. Back Matter
    Pages 297-300

About this book

Introduction

This edited volume is composed of chapters written by experts in the field describing fundamental research on small peptide fragments in relation to their biological action and potential roles in biomedical applications from diagnosis to implant protection. It provides a review of the wide scope and significance of these relatively simple arrays of amino acids that have the ability to bind to surfaces of all kinds and can facilitate the autonomous assembly of structures in nanotechnology as well as penetrating cell membranes and delivering therapeutic drugs. Readers will learn of some of the impediments to a wider and more comprehensive catalog of these molecules and of some of the attributes of rationally-designed and chemically synthesised peptides as anticancer agents.

An overview is provided of the expansive variety of biological leads for biomedically relevant peptides as well as the wide array of tissues and biological, bioactive scaffolds that are dependent on these short peptide sequences addressing topics such as cartilage and hard tissue initiation and regeneration and the transition of active reagents from molluscs to drug leads for the treatment of chronic pain. Peptides can possess surface-specific non-covalent adsorption properties that can be exploited to enhance the functionality of medical implant materials but their implementation is largely on a trial-and-error basis because an understanding of general structure/function relationships is lacking. Molecular simulation approaches can provide relevant details at the atomic scale and prospects for advancing peptide-mediated medical implant surface treatments via molecular simulation are summarized. The literature has papers emphasizing the role of peptides in the design of biohybrid functional surfaces and there has been a growing interest in applying peptides as materials-selective assemblers and self-organizers, but applications are based largely on an empirical understanding of solid surface binding characteristics, as reviewed here.

The present work is written for researchers who may be considering entering this field and are exposed to a mass of fundamental research information on individual applications.  It has been our intention to trace how and where the research has emerged and to outline the opportunities we see to develop novel and well-grounded tools for specific therapeutic scenarios.

Keywords

Peptides Biopolymers Biomedicine Nanomaterials Biomaterials

Editors and affiliations

  • Anwar Sunna
    • 1
  • Andrew Care
    • 2
  • Peter L. Bergquist
    • 3
  1. 1.Department of Chemistry and Biomolecular SciencesMacquarie UniversityNorth RydeAustralia
  2. 2.Biomolecular Discovery and Design, Research CentreMacquarie UniversityNorth RydeAustralia
  3. 3.Department of Chemistry and Biomolecular SciencesMacquarie UniversityNorth RydeAustralia

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-66095-0
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-66094-3
  • Online ISBN 978-3-319-66095-0
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site