Table of contents

  1. Front Matter
    Pages i-viii
  2. Biological and Physical Fundamentals

    1. Front Matter
      Pages 7-7
    2. Sebastian Hirsch, Tobias Schaeffter, Ingolf Sack
      Pages 9-43
    3. Alfonso Caiazzo, Irene E. Vignon-Clementel
      Pages 45-70
    4. Hans Kubitschke, Erik W. Morawetz, Josef A. Käs, Jörg Schnauß
      Pages 89-121
    5. Angela Ariza de Schellenberger, Judith Bergs, Ingolf Sack, Matthias Taupitz
      Pages 123-150
  3. Medical Imaging Technologies

    1. Front Matter
      Pages 151-151
    2. Gitta Kutyniok, Jackie Ma, Maximilian März
      Pages 153-166
    3. Christoph Kolbitsch, Tobias Schaeffter
      Pages 167-186
    4. Sebastian Schmitter, Susanne Schnell
      Pages 187-212
    5. Martin Kunth, Leif Schröder
      Pages 213-253
    6. Ulrich Abram
      Pages 255-279
    7. Heiko Tzschätzsch
      Pages 281-302
  4. Applications

    1. Front Matter
      Pages 341-341
    2. Julia Brangsch, Carolin Reimann, Marcus R. Makowski
      Pages 373-381
    3. Winfried Brenner, Florian Wedel, Janet F. Eary
      Pages 395-410
    4. Thomas Fischer, Anke Thomas, Dirk-André Clevert
      Pages 411-427
    5. Jing Guo, Florian Dittmann, Jürgen Braun
      Pages 429-449
    6. Ralph Buchert
      Pages 451-469
    7. Amedeo Chiribiri
      Pages 471-485
    8. Marc Dewey, Marc Kachelrieß
      Pages 487-497

About this book


This book provides a selection of essential knowledge on the image-based quantification of biophysical parameters for the purpose of clinical diagnosis. The authors regard clinical imaging scanners as physical measurement systems capable of quantifying intrinsic parameters for depiction of the constitution and biophysical properties of in vivo tissue. On the one hand, this approach supports the development of new methods of imaging highly reproducible, system-independent, and quantitative biomarkers, and these methods receive detailed attention in the book. On the other hand, the reader will also gain a deeper understanding of how physical tissue properties interact with the generation of signals in medical imaging, opening new windows on the intricate and fascinating relationship between the structure and function of living tissues. The book will be of interest to all who recognize the limitations of basing clinical diagnosis primarily on visual inspection of images and who wish to learn more about the diagnostic potential of quantitative and biophysics-based medical imaging markers and the challenges that the paucity of such markers poses for next-generation imaging technologies.


Quantitative medical imaging Biophysical tissue properties Medical technology Parameter mapping Imaging technology Biophysics-based medical imaging markers Imaging biomarkers Imaging physics Medical image processing

Editors and affiliations

  • Ingolf Sack
    • 1
  • Tobias Schaeffter
    • 2
  1. 1.Department of RadiologyHumboldt University of Berlin Charité University HospitalBerlinGermany
  2. 2.Medical Physics and Metrological Information TechnologyPhysikalisch-Technische Bundesanstalt BerlinGermany

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-65923-7
  • Online ISBN 978-3-319-65924-4
  • Buy this book on publisher's site