Progressive Multiple Sclerosis

  • Alastair¬†Wilkins

Table of contents

  1. Front Matter
    Pages i-ix
  2. Alastair Wilkins, Stanley Hawkins
    Pages 1-29
  3. Katharine Harding, Neil Robertson
    Pages 31-47
  4. Nikos Evangelou, Simon M. L. Paine, Emma C. Tallantyre
    Pages 49-69
  5. Alastair Wilkins
    Pages 71-92
  6. Declan Chard, Olga Ciccarelli
    Pages 93-121
  7. Axel Petzold
    Pages 123-154
  8. Steven M. Bailey, Claire M. Rice
    Pages 155-205
  9. Michael Hutchinson, David P. J. Hunt
    Pages 207-232
  10. R. S. Nicholas, A. Nandoskar, M. Hutchinson, T. Friede
    Pages 233-252
  11. Jennifer Freeman
    Pages 253-274
  12. Back Matter
    Pages 301-307

About this book


This revised, updated second edition draws together the basic science, pathology, epidemiology and treatment possibilities in progressive multiple sclerosis. Each chapter addresses specific aspects of progressive multiple sclerosis providing an extensive review of the current literature and a discussion of the likely mechanisms of tissue injury relevant to the disease. New additions to the second edition include a description of clinical scales used to determine levels of disability; recent trials specifically directed at reducing disease progression; rehabilitation; and an in depth discussion of the similarities and differences between primary and secondary multiple sclerosis.

The biological processes underlying disease progression are elucidated as are specific pathophysiological mechanisms. The basic science of axonal degeneration and the clinical understanding of progressive multiple sclerosis are discussed in the context of emerging and future therapies for disease progression as are trials which have been and will be conducted for progressive multiple sclerosis. An overview of biomarkers for the disease is included and existing symptomatic therapies for progressive multiple sclerosis are covered in detail.

Progressive Multiple Sclerosis, Second Edition is ideal for both general neurologists and those with a specialist interest in multiple sclerosis. It will also be of interest to neurologists in training and other medical professionals treating this common disease.


multiple sclerosis biomarkers MS multiple sclerosis epidemiology Multiple Sclerosis multiple sclerosis pathophysiology Progressive multiple sclerosis multiple sclerosis therapy multiple sclerosis clinical scale axonal injury

Editors and affiliations

  • Alastair¬†Wilkins
    • 1
  1. 1.Southmead HospitalUniversity of BristolBristolUnited Kingdom

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-65920-6
  • Online ISBN 978-3-319-65921-3
  • Buy this book on publisher's site