Coupling and Decoupling of Diverse Molecular Units in Glycosciences

  • Zbigniew J. Witczak
  • Roman Bielski

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Renata Kowalczyk, Harveen Kaur, Antony J. Fairbanks, Margaret A. Brimble
    Pages 1-36
  3. Sri Kumar Veleti, Steven J. Sucheck
    Pages 91-107
  4. Gour Chand Daskhan, Malyasree Giri, Narayanaswamy Jayaraman
    Pages 133-154
  5. Nathaniel S. Schocker, Susana Portillo, Roger A. Ashmus, Carlos R. N. Brito, Igor E. Silva, Yanira Cordero Mendoza et al.
    Pages 195-211
  6. Yoshiko Miura, Tomohiro Fukuda, Hirokazu Seto, Yu Hoshino
    Pages 213-224
  7. Christopher Gray, Sabine L. Flitsch
    Pages 225-267
  8. Belén Rubio-Ruiz, Thomas L. Bray, Ana M. López-Pérez, Asier Unciti-Broceta
    Pages 269-298
  9. Colin M. Hayman, Ian F. Hermans, Gavin F. Painter
    Pages 309-335

About this book


This unique book covers the latest developments in coupling and decoupling of biomolecules containing functionalized carbohydrate components, being one of the first collections in this important area of applied medicinal chemistry.

Connecting molecules, often referred as bio-conjugation, has become one of the most often performed procedures in modern medicinal chemistry. Sometimes, when the connected molecules are not useful anymore, they must be disconnected. The molecules that must be connected (coupled) may belong to both small and large molecules and include such constructs as glycoproteins, glycopeptides and glycans.

In this work, more than 15 experts address a comprehensive range of potential and current uses of in vitro and in vivo bio-conjugation methodologies, leading to a variety of glycoconjugates. The analytical aspects of bio-conjugation are also here discussed. Medicinal and organic chemists from graduate level onwards will understand the appeal of this important book.


bio-conjugation biomaterials synthesis of glycopeptides synthesis of glycoproteins synthesis of glycosides thio-sugars levoglucosenone synthesis of cellular sugars in-vivo bioconjugation in-vitro bioconjugation

Editors and affiliations

  • Zbigniew J. Witczak
    • 1
  • Roman Bielski
    • 2
  1. 1.Pharmaceutical Sciences DepartmentWilkes UniversityWilkes-BarreUSA
  2. 2.Pharmaceutical Sciences Department, Nesbitt School of PharmacyWilkes UniversityWilkes-BarreUSA

Bibliographic information