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CFTR and Cystic Fibrosis

From Structure to Function

  • Carlos M.  Farinha

Part of the SpringerBriefs in Molecular Science book series (BRIEFSMOLECULAR)

Also part of the Protein Folding and Structure book sub series (BRIEFSPROTEIN)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Carlos M. Farinha
    Pages 1-56

About this book

Introduction

This Brief is devoted to the CFTR protein and cystic fibrosis, and it provides an updated perspective of the genetic, functional and cellular processes involved in this conformational disorder. Starting with a historical perspective on cystic fibrosis and its clinical features, the author departs into an in-depth description of the biology of the CFTR protein, ending with a discussion on the latest approaches aimed at developing corrective therapies for cystic fibrosis.

First the basic aspects of cystic fibrosis as a disorder are addressed, focusing on genetics and mutation prevalence. Then the CFTR protein is discussed in detail: its structure and classification within the ABC transporter superfamily, its biogenesis with membrane insertion and chaperone assisted folding, its glycosylation and how it regulates the endoplasmatic reticulum quality control mechanisms that assess CFTR folding status. Extra attention is given to post-ER trafficking and regulation of membrane stability and anchoring, and to CFTR functions. This is linked to the molecular mechanisms through which different CFTR mutations cause cystic fibrosis. Finally, the different efforts aiming at rescuing the basic defect, most of which aim at repairing CFTR dysfunction, are covered.

Through this integrated perspective, readers will obtain a unique insight into this fascinating membrane-bound protein and its associated disease. This Brief appeals to an audience interested in human genetics, protein folding, protein trafficking and physiology. 

Keywords

CFTR cystic Fibrosis protein folding protein trafficking membrane proteins ion channels ABC transporters post-translational modification ERQC glycosylation

Authors and affiliations

  • Carlos M.  Farinha
    • 1
  1. 1.Department of Chemistry and Biochemistry, BioISI—Biosystems and Integrative Sciences InstituteUniversity of LisboaLisboaPortugal

Bibliographic information