Acute Promyelocytic Leukemia

A Clinical Guide

  • Oussama Abla
  • Francesco Lo Coco
  • Miguel A. Sanz

Table of contents

  1. Front Matter
    Pages i-xii
  2. Laurent Degos
    Pages 1-16
  3. Ramy Rahmé, Cécile Esnault, Hugues de Thé
    Pages 17-27
  4. Thalia Vlachou, Giulia De Conti, Anna Giulia Sanarico, Pier Giuseppe Pelicci
    Pages 29-40
  5. Lourdes Mendez, Ming Chen, Pier Paolo Pandolfi
    Pages 41-53
  6. Anna Falanga, Laura Russo, Pau Montesinos
    Pages 55-70
  7. Sören Lehmann
    Pages 71-86
  8. Javier de la Serna, Pau Montesinos, Miguel A. Sanz
    Pages 87-98
  9. Aaron D. Goldberg, Martin S. Tallman
    Pages 99-112
  10. Mary-Elizabeth M. Percival, Elihu H. Estey
    Pages 133-151
  11. Laura Cicconi, Eva Barragàn
    Pages 153-161
  12. Eva Lengfelder
    Pages 163-170
  13. Jaime Sanz, Miguel A. Sanz
    Pages 171-177
  14. Matthew A. Kutny, Anna Maria Testi
    Pages 179-195
  15. Ramy Rahmé, Lionel Adès, Pierre Fenaux
    Pages 197-201
  16. Massimo Breccia, Gloria Iacoboni, Miguel A. Sanz
    Pages 203-210
  17. Luisa Corrêa de Araújo Koury, Raul Ribeiro, Eduardo M. Rego
    Pages 211-216
  18. Kristen Pettit, Richard A. Larson
    Pages 231-242
  19. Ombretta Annibali, Giuseppe Avvisati
    Pages 257-267
  20. Back Matter
    Pages 269-274

About this book


This book provides a comprehensive overview on the clinical issues and biology of acute promyelocytic leukemia (APL) and on the molecular mechanisms of targeted therapy with ATRA and ATO. The text covers major topics such as the pathophysiology of APL coagulopathy, biologic and clinical differences between children and adults with APL, and the role of minimal residual disease monitoring. Additionally, the book summarizes historical, current, and future treatment strategies in both adults and children, while highlighting the most recent therapeutic recommendations for relapsed disease and the evolving indications for autologous and allogeneic stem cell transplant. This volume also features chapters focusing on secondary APL and therapy, late effects, rare presentations such as APL in the elderly and during pregnancy, and rare APL variants that may represent therapeutic challenges.

Written by top experts in the field, Acute Promyelocytic Leukemia: A Clinical Guide is a valuable resource for clinicians and researchers who treat and investigate this disease in children and adults.


APL Animal Models APL coagulopathy ATRA-ATO MRD monitoring autologous stem cell transplant allogeneic stem cell transplant

Editors and affiliations

  • Oussama Abla
    • 1
  • Francesco Lo Coco
    • 2
  • Miguel A. Sanz
    • 3
  1. 1.Division of Hematology/OncologyThe Hospital for Sick Children and University of TorontoTorontoCanada
  2. 2.Department of HematologyUniversity of Tor VergataRomeItaly
  3. 3.Department of MedicineHospital Universitari i Politecnic La Fe, University of ValenciaValenciaSpain

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-64256-7
  • Online ISBN 978-3-319-64257-4
  • Buy this book on publisher's site