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A Network-Based Approach to Cell Metabolism

From Structure to Flux Balances

  • Oriol Güell

Part of the Springer Theses book series (Springer Theses)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Oriol Güell
    Pages 25-52
  3. Oriol Güell
    Pages 131-135
  4. Back Matter
    Pages 137-151

About this book

Introduction

This thesis uses a systems-level approach to study the cellular metabolism, unveiling new mechanisms and responses that were impossible to reach with traditional reductionists procedures.

The results reported here have a potential application in areas like metabolic engineering and disease treatment. They could also be used in determining the accuracy of the gene essentiality of new genome-scale reconstructions.

Different methods and techniques, within the contexts of Systems Biology and the field known as Complex Networks Analysis have been applied in this work to show different features of the robustness of metabolic networks. The specific issues addressed here range from pure topological aspec

ts of the networks themselves to the balance of biochemical fluxes.

 

 

Keywords

Chemical Biology Physical Chemistry Metabolic Networks Complex Networks Flux Balance Analysis

Authors and affiliations

  • Oriol Güell
    • 1
  1. 1.Department of Materials Science and Physical ChemistryUniversity of BarcelonaBarcelonaSpain

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-64000-6
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-3-319-63999-4
  • Online ISBN 978-3-319-64000-6
  • Series Print ISSN 2190-5053
  • Series Online ISSN 2190-5061
  • Buy this book on publisher's site