Extracellular Matrix in Tumor Biology

  • Rolf A. Brekken
  • Dwayne Stupack

Part of the Biology of Extracellular Matrix book series (BEM)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Dorota Ewa Kuczek, Mie Linder Hübbe, Daniel Hargbøl Madsen
    Pages 17-38
  3. Michael Pratt, Ya’an Kang, Xinqun Li, Jason B. Fleming
    Pages 39-49
  4. Paul A. Keire, Inkyung Kang, Thomas N. Wight
    Pages 51-74

About this book


This volume provides an overview on the influence of Extracellular Matrix (ECM) on tumor progression. It covers topics such as signaling induced by structural ECM proteins including collagen and fibronectin, the control of ECM deposition and the turnover in tumors. Also discussed are the migration of cells through basement membranes and the function of proteoglycans including lumican and veriscan in tumor progression. Biomaterial-based in-vitro models as well as C. elegans models of the tumor microenvironment are used to show how these models can lead to a greater understanding of the disease mechanisms that promote cancer progression.  The book addresses researchers working on cancer biology or ECM, and oncologists alike.


Tumor progression Collagen Fibronectin Versican Lumican SPARC

Editors and affiliations

  • Rolf A. Brekken
    • 1
  • Dwayne Stupack
    • 2
  1. 1.Hamon Center for Therapeutic Oncology ResearchUT Southwestern Medical Center DallasUSA
  2. 2.Department of Reproductive MedicineUniversity of California La JollaUSA

Bibliographic information