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Tumor Organoids

  • Shay Soker
  • Aleksander Skardal

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Cameron Yamanishi, Kimberly Jen, Shuichi Takayama
    Pages 1-15
  3. Estela Solanas, Iris Pla-Palacín, Pilar Sainz-Arnal, Manuel Almeida, Alberto Lue, Trinidad Serrano et al.
    Pages 17-33
  4. Rocío Sampayo, Sol Recouvreux, María Inés Diaz Bessone, Marina Simian
    Pages 35-49
  5. Andrea Mazzocchi, Shay Soker, Aleksander Skardal
    Pages 51-70
  6. Manasa Gadde, Dan Marrinan, Rhys J. Michna, Marissa Nichole Rylander
    Pages 71-94
  7. Aaron E. Chiou, Claudia Fischbach
    Pages 95-116
  8. Venktesh S. Shirure, Mary Kathryn Sewell-Loftin, Sandra F. Lam, Tyson D. Todd, Priscilla Y. Hwang, Steven C. George
    Pages 117-148
  9. Shiny Amala Priya Rajan, Parker Hambright, Rosemary Clare Burke, Adam R. Hall
    Pages 149-170
  10. Amanda M. Smelser, Manuel M. Gomez, Scott Smyre, Melissa L. Fender Pashayan, Jed C. Macosko
    Pages 171-191
  11. Aleksandra Karolak, Katarzyna A. Rejniak
    Pages 193-213

About this book

Introduction

Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Keywords

3-D Human Tissue Anti-Cancer Drug Development In Vivo Organoids Stroma Tumor

Editors and affiliations

  • Shay Soker
    • 1
  • Aleksander Skardal
    • 2
  1. 1.Institute for Regenerative MedicineWake Forest School of MedicineWinston-SalemUSA
  2. 2.Institute for Regenerative MedicineWake Forest School of MedicineWinston-SalemUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-60511-1
  • Copyright Information Springer International Publishing AG 2018
  • Publisher Name Humana Press, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-60509-8
  • Online ISBN 978-3-319-60511-1
  • Series Print ISSN 2196-9906
  • Series Online ISSN 2196-9914
  • Buy this book on publisher's site