Biology and Pathology of Perineuronal Satellite Cells in Sensory Ganglia

  • Ennio Pannese

Part of the Advances in Anatomy, Embryology and Cell Biology book series (ADVSANAT, volume 226)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Back Matter
    Pages 65-83

About this book


This volume provides a comprehensive and updated review of perineuronal satellite cells in sensory ganglia. For a long time since their discovery by Valentin in the first half of the 19th century these cells received only modest attention. However, some years ago research findings suggested that satellite cells play a role in the development and maintenance of neuropathic pain. As a result, satellite cells are now considered as possible targets for neuropathic pain treatment. Thus, interest in satellite cells has burgeoned. The review is based on the author’s own work as well as on his critical evaluation and systematic arrangement of data scattered through a large number of research papers. The following aspects of perineuronal satellite cells are covered: Shape and structure; molecular characteristics; origin and development; biological and functional properties; relationships with the ganglion sensory neuron; age-related changes; roles under physiological conditions; reactions to experimental and pathological conditions; role in neuropathic pain.


perikaryal myelin sheaths interstitial connective tissue perineuronal microenvironment hereditary neuropathies neuropathic pain neuroprotection

Authors and affiliations

  • Ennio Pannese
    • 1
  1. 1.University of MilanMilanItaly

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-60139-7
  • Online ISBN 978-3-319-60140-3
  • Series Print ISSN 0301-5556
  • Series Online ISSN 2192-7065
  • Buy this book on publisher's site