Centromeres and Kinetochores

Discovering the Molecular Mechanisms Underlying Chromosome Inheritance

  • Ben E. Black

Part of the Progress in Molecular and Subcellular Biology book series (PMSB, volume 56)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Identification, Organization, and Regulation of Centromere and Kinetochore Components

    1. Front Matter
      Pages 1-1
    2. Itaru Samejima, Melpomeni Platani, William C. Earnshaw
      Pages 3-27
    3. Steven Friedman, Michael Freitag
      Pages 85-109
    4. Ines A. Drinnenberg, Bungo Akiyoshi
      Pages 111-138
  3. Epigenetic Contributions to Centromere Identity and Function

    1. Front Matter
      Pages 163-163
    2. Ewelina Zasadzińska, Daniel R. Foltz
      Pages 165-192
    3. Ana García del Arco, Sylvia Erhardt
      Pages 213-231
    4. Shannon M. McNulty, Beth A. Sullivan
      Pages 233-255
    5. Zachary Duda, Sarah Trusiak, Rachel O’Neill
      Pages 257-281
  4. The Role of DNA Sequence in Centromere Identity and Function

    1. Front Matter
      Pages 283-283
    2. M. Dumont, D. Fachinetti
      Pages 305-336
    3. Elena Giulotto, Elena Raimondi, Kevin F. Sullivan
      Pages 337-354
  5. The Functions and Mechanisms of Centromeres and Kinetochores in Healthy Meiotic and Mitotic Divisions and their Role in Human Disease

    1. Front Matter
      Pages 355-355
    2. Elaine M. Dunleavy, Collins Caitríona M.
      Pages 357-375
    3. Lukáš Chmátal, Richard M. Schultz, Ben E. Black, Michael A. Lampson
      Pages 377-396
    4. Ekaterina L. Grishchuk
      Pages 397-428
    5. Giulia Vallardi, Marilia Henriques Cordeiro, Adrian Thomas Saurin
      Pages 457-484
    6. Mihailo Mirkovic, Raquel A. Oliveira
      Pages 485-513
    7. Kerry Bloom, Vincenzo Costanzo
      Pages 515-539
    8. Thian Thian Beh, Paul Kalitsis
      Pages 541-554

About this book


This book presents the latest advances concerning the regulation of chromosome segregation during cell division by means of centromeres and kinetochores. The authors cover both state-of-the-art techniques and a range of species and model systems, shedding new light on the molecular mechanisms controlling the transmission of genetic material between cell divisions and from parent to offspring. 

The chapters cover five major areas related to the current study of centromeres and kinetochores: 1) their genetic and epigenetic features, 2) key breakthroughs at the molecular, proteomic, imaging and biochemical level, 3) the constitutive centromere proteins, 4) the role of centromere proteins in the physical process of chromosome segregation and its careful orchestration through elaborate regulation, and 5) intersections with reproductive biology, human health and disease, as well as chromosome evolution. The book offers an informative and provocative guide for newcomers as well as those already acquainted with the field.


centomeres kinetochores chromatin chromosome segregation epigenetics mitosis

Editors and affiliations

  • Ben E. Black
    • 1
  1. 1.Department of Biochemistry and BiophysicsPerelman School of Medicine at the University of PennsylvaniaPhiladelphiaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-58591-8
  • Online ISBN 978-3-319-58592-5
  • Series Print ISSN 0079-6484
  • Series Online ISSN 2197-8484
  • Buy this book on publisher's site