Metal Allergy

From Dermatitis to Implant and Device Failure

  • Jennifer K Chen
  • Jacob P. Thyssen

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Metal: Overview

    1. Front Matter
      Pages 1-1
    2. C. Peter Cutler
      Pages 3-16
    3. Morten Stendahl Jellesen
      Pages 17-22
    4. Ines Anderie, Kerstin Schulte
      Pages 31-38
  3. Metals, Skin, and the Immune System

    1. Front Matter
      Pages 55-55
    2. Francesca Larese Filon
      Pages 67-74
    3. Marc Schmidt, Matthias Goebeler
      Pages 75-84
    4. Trine Hilkjær Petersen, Carsten Geisler, Charlotte Menné Bonefeld
      Pages 85-95
    5. Angela Rizzi, Eleonora Nucera, Domenico Schiavino
      Pages 97-105
    6. Radoslaw Spiewak
      Pages 107-124
    7. Thomas Rustemeyer
      Pages 125-133
  4. Common Sources of Metal Exposure

    1. Front Matter
      Pages 135-135
    2. Carsten R. Hamann, Dathan Hamann
      Pages 137-162
    3. Vera Mahler
      Pages 163-175
    4. Malgorzata M. Brzóska, Malgorzata Galażyn-Sidorczuk, Sylwia Borowska
      Pages 177-196
    5. Kelsey E. Hirotsu, Jennifer K. Chen
      Pages 197-209
    6. Matthew J. Zirwas
      Pages 211-225
    7. Manohar Mahato, Nicholas E. Sherman, N. Kiran Kumar Mudnakudu, Nitin Joshi, Elisabeth Briand, Jeffrey M. Karp et al.
      Pages 227-246
  5. Hypersensitivity to Metallic Implants

    1. Front Matter
      Pages 247-247
    2. Lauren N. Ko, Peter C. Schalock
      Pages 249-262
    3. Cecilia Svedman, Magnus Bruze
      Pages 263-271
    4. Joris Muris, Cees J. Kleverlaan
      Pages 285-300
    5. Kerry Heitmiller, Danielle Baruch, Anthony A. Gaspari
      Pages 301-320
    6. Peter Thomas, Burkhard Summer
      Pages 321-330
  6. Allergens

    1. Front Matter
      Pages 331-331
    2. Monica Hindsén
      Pages 333-336
    3. James S. Taylor, Raed A. Dweik, Jane M. Taylor
      Pages 337-347
    4. Yolanda S. Hedberg
      Pages 349-364
    5. Anneli Julander
      Pages 365-372
    6. Simon W. Fage
      Pages 373-386
    7. Cecilia Svedman, Magnus Bruze
      Pages 387-395
    8. Gianpaolo Guzzi, Paolo D. Pigatto
      Pages 397-421
    9. Carola Lidén
      Pages 423-434
    10. Joris Muris, Cees J. Kleverlaan
      Pages 435-442
    11. Curt Hamann
      Pages 443-466
    12. Andreas J. Bircher
      Pages 467-479
  7. Metal Allergy in Select Patient Populations

    1. Front Matter
      Pages 481-481
    2. Richard Brans, Swen M. John
      Pages 483-493
    3. Chandler Rundle, Nikoleta Brankov, Sharon E. Jacob
      Pages 495-506
    4. John McFadden
      Pages 507-513
    5. Anthony Goon
      Pages 515-520
  8. Uncommon Manifestations of Metal Allergy

    1. Front Matter
      Pages 521-521
    2. Niels H. Bennike, Majken H. Foss-Skiftesvik
      Pages 523-531
    3. Cezary Pałczyński, Maciej Kupczyk
      Pages 533-544
    4. Paolo D. Pigatto, Gianpaolo Guzzi
      Pages 545-549

About this book


This volume has been compiled in response to the ongoing revolution in our understanding of metal contact allergy, and the ensuing challenge this has created for clinicians and others to synthesize large amounts of sometimes contradictory data. It opens by providing a comprehensive overview of the use and regulation of metals in our society, metal properties, and available testing methodologies. Common and uncommon metal allergens and sources of exposure are then reviewed in depth, and detailed sections are devoted to hypersensitivity to metal implants (which may be associated with device failure and/or dermatitis), metal allergy in select patient populations, and less frequently encountered manifestations of metal allergy.

The prevalence of metal allergy in the general population is high: up to 17% of people are allergic to nickel, and 1–3% to cobalt and chromium. Environmental sources of metal exposure include jewelry, clothing, electronic devices, coins, leather, diet, and occupational exposure. As metals are ubiquitous, this book will be an indispensable reference text for a wide range of clinicians and investigators, meeting the needs of all who are interested in metal allergy and its diagnosis and management.




Metallic Implants Allergic contact dermatitis Nickel Contact allergy Patch testing Metal exposure Metal allergy

Editors and affiliations

  • Jennifer K Chen
    • 1
  • Jacob P. Thyssen
    • 2
  1. 1.Department of Dermatology, Stanford University School of MedicineRedwood CityUSA
  2. 2.Department of Dermatology and Allergy Herlev and Gentofte Hospital University of CopenhagenHellerupDenmark

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-58502-4
  • Online ISBN 978-3-319-58503-1
  • Buy this book on publisher's site